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Occupational exposure to extremely low frequency magnetic fields and brain tumour risks in the INTEROCC study Public Deposited

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  • BACKGROUND: Occupational exposure to extremely low frequency magnetic fields (ELF) is a suspected risk factor for brain tumours, however the literature is inconsistent. Few studies have assessed whether ELF in different time windows of exposure may be associated with specific histologic types of brain tumours. This study examines the association between ELF and brain tumours in the large-scale INTEROCC study. METHODS: Cases of adult primary glioma and meningioma were recruited in seven countries (Australia, Canada, France, Germany, Israel, New Zealand, United Kingdom) between 2000 and 2004. Estimates of mean workday ELF exposure based on a job exposure matrix assigned. Estimates of cumulative exposure, average exposure, maximum exposure, and exposure duration were calculated for the lifetime, and 1-4, 5-9, and 10+ years prior to the diagnosis/reference date. RESULTS: There were 3,761 included brain tumour cases (1,939 glioma, 1,822 meningioma) and 5,404 population controls. There was no association between lifetime cumulative ELF exposure and glioma or meningioma risk. However, there were positive associations between cumulative ELF 1-4 years prior to the diagnosis/reference date and glioma (odds ratio (OR) ≥ 90th percentile vs < 25th percentile = 1.67, 95% confidence interval (CI) 1.36-2.07, p < 0.0001 linear trend), and, somewhat weaker associations with meningioma (OR ≥ 90th percentile vs < 25th percentile = 1.23, 95% CI 0.97-1.57, p = 0.02 linear trend). CONCLUSIONS: Results showed positive associations between ELF in the recent past and glioma. IMPACT: Occupational ELF exposure may play a role in the later stages (promotion and progression) of brain tumourigenesis.
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  • Turner, M. C., Benke, G., Bowman, J. D., Figuerola, J., Fleming, S., Hours, M., ... & Cardis, E. (2014). Occupational exposure to extremely low-frequency magnetic fields and brain tumor risks in the INTEROCC study. Cancer Epidemiology Biomarkers & Prevention, 23(9), 1863-1872. doi:10.1158/1055-9965.EPI-14-0102
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  • 23
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  • 9
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  • Michelle C Turner was funded by a Government of Canada BantingPostdoctoral Fellowship. The INTEROCC study was funded by the National Institutes forHealth (NIH) Grant No. 1R01CA124759 (PI E Cardis). Coding of the French occupational datawas in part funded by AFSSET (Convention N° ST-2005-004). The INTERPHONE study wassupported by funding from the European Fifth Framework Program, ‘Quality of Life andManagement of Living Resources’ (contract 100 QLK4-CT-1999901563) and the InternationalUnion against Cancer (UICC). The UICC received funds for this purpose from the MobileManufacturers’ Forum and GSM Association. In Australia, funding was received from theAustralian National Health and Medical Research 5 Council (EME Grant 219129) with fundsoriginally derived from mobile phone service license fees; a University of Sydney MedicalFoundation Program; the Cancer Council NSW and The Cancer Council Victoria. In Canadafunding was received from the Canadian Institutes of Health Research (project MOP-42525); theCanada Research Chair programme; the Guzzo-CRS Chair in Environment and Cancer; theFonds de la recherche en santé du Québec; the Canadian Institutes of Health Research (CIHR),the latter including partial support from the Canadian Wireless Telecommunications Association;the NSERC Chair in Risk Science at the University of Ottawa. In France, funding was receivedby l’Association pour la Recherche sur le Cancer (ARC) (Contrat N85142) and three networkoperators (Orange, SFR, Bouygues Telecom). In Germany, funding was received from theGerman Mobile Phone Research Program (Deutsches Mobilfunkforschungsprogramm) of theGerman Federal Ministry for the Environment, Nuclear 45 Safety, and Nature Protection; theMinistry for the Environment and Traffic of the state of Baden-Wurttemberg; the Ministry forthe Environment of the state of North Rhine-Westphalia; the MAIFOR Program (MainzerForschungsforderungsprogramm) of the University of Mainz. In New Zealand, funding wasprovided by the Health Research Council, Hawkes Bay Medical Research Foundation, theWellington Medical Research Foundation, the Waikato Medical Research Foundation and theCancer Society of New Zealand. Additional funding for the UK study was received from theMobile Telecommunications, Health and Research (MTHR) program, funding from the Healthand Safety Executive, the Department of Health, the UK Network Operators (O2, Orange, T-Mobile,Vodafone, ‘3’) and the Scottish Executive.
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  • description.provenance : Submitted by Erin Clark (erin.clark@oregonstate.edu) on 2015-03-02T21:20:11Z No. of bitstreams: 2 KinclLaurelPHHSOccupationalExposureExtremely.pdf: 539168 bytes, checksum: 8f7d60f70fdfc1e2b0f0e02330e92286 (MD5) KinclLaurelPHHSOccupationalExposureExtremely_DataSupplement.pdf: 139122 bytes, checksum: 8aa6a900109d3304f3a598df9cc59e05 (MD5)
  • description.provenance : Made available in DSpace on 2015-03-02T21:20:57Z (GMT). No. of bitstreams: 2 KinclLaurelPHHSOccupationalExposureExtremely.pdf: 539168 bytes, checksum: 8f7d60f70fdfc1e2b0f0e02330e92286 (MD5) KinclLaurelPHHSOccupationalExposureExtremely_DataSupplement.pdf: 139122 bytes, checksum: 8aa6a900109d3304f3a598df9cc59e05 (MD5) Previous issue date: 2014-09
  • description.provenance : Approved for entry into archive by Erin Clark(erin.clark@oregonstate.edu) on 2015-03-02T21:20:56Z (GMT) No. of bitstreams: 2 KinclLaurelPHHSOccupationalExposureExtremely.pdf: 539168 bytes, checksum: 8f7d60f70fdfc1e2b0f0e02330e92286 (MD5) KinclLaurelPHHSOccupationalExposureExtremely_DataSupplement.pdf: 139122 bytes, checksum: 8aa6a900109d3304f3a598df9cc59e05 (MD5)

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