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Hypertension and low HDL cholesterol were associated with reduced kidney function across the age spectrum: a collaborative study Public Deposited

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  • Purpose: To determine if the associations among established risk factors and reduced kidney function vary by age. Methods: We pooled cross-sectional data from 14,788 nondiabetics aged 40 to 100 years in 4 studies: Cardiovascular Health Study, Health, Aging, and Body Composition Study, Multi-Ethnic Study of Atherosclerosis, and Prevention of Renal and Vascular End-Stage Disease cohort. Results: Hypertension and low high-density lipoprotein (HDL) cholesterol were associated with reduced cystatin C-based estimated glomerular filtration rate (eGFR) across the age spectrum. In adjusted analyses, hypertension was associated with a 23 (95% confidence interval [CI], 0.1, 4.4), 5.1 (95% Cl, 4.1, 6.1), and 6.9 (95% CI, 3.0, 10.4) mL/min/1.73 m(2) lower eGFR in participants 40 to 59, 60 to 79, and at least 80 years, respectively (P for interaction < .001). The association of low HDL cholesterol with reduced kidney function was also greater in the older age groups: 4.9 (95% CI, 3.5, 6.3), 7.1 (95% CI, 6.0, 83), 8.9 (95% CI, 5.4,11.9) mL/min/1.73 m(2) (P for interaction < .001). Smoking and obesity were associated with reduced kidney function in participants under 80 years. All estimates of the potential population impact of the risk factors were modest. Conclusions: Hypertension, obesity, smoking, and low HDL cholesterol are modestly associated with reduced kidney function in nondiabetics. The associations of hypertension and HDL cholesterol with reduced kidney function seem to be stronger in older adults. (C) 2013 Elsevier Inc. All rights reserved.
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  • Odden, M. C., Sarnak, M. J., Siscovick, D., Shlipak, M. G., Tager, I. B., Gansevoort, R. T., . . . Harris, T. B. (2013). Hypertension and low HDL cholesterol were associated with reduced kidney function across the age spectrum: A collaborative study. Annals of Epidemiology, 23(3), 106-111. doi: 10.1016/j.annepidem.2012.12.004
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  • 23
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  • 3
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  • Heart, Lung, and Blood Institute (NHLBI) contracts N01-HC-85239, N01-HC-85079 through N01-HC-85086; N01-HC-35129, N01 HC- 15103, N01 HC-55222, N01-HC-75150, N01-HC-45133 and NHLBI grant HL080295, with additional contribution from National Institute of Neurological Disorders and Stroke. Additional support was provided through AG-023629, AG-15928, AG-20098, and AG- 027058 from the National Institute on Aging (NIA). See also http://www.chs-nhlbi.org/pi.htm. Health ABC was supported through the NIA contracts N01-AG-6-2101, N01-AG-6-2103, and N01-AG-6-2106; NIA grant R01-AG028050, and National Institute of Nursing Research grant R01-NR012459. In addition, this research was supported in part by the Intramural Research Program of the NIH, NIA. MESA was supported by grant R01-HL-63963-01A1 and by contracts N01-HC-95159 through N01-HC-95165 and N01-HC- 95169 from the NHLBI. PREVEND is supported by grant E013 of the Dutch Kidney Foundation, Bussum, The Netherlands, and grants T32DK07791 and DK52866 from the National Institute of Diabetes and Digestive, and Kidney Diseases. This projectwas also supported by grant R01AG027002 from the NIA. Dr. Odden is supported by a the American Heart Association Western States Affiliate Clinical Research Program and the National Institute on Aging (K01AG039387).
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  • description.provenance : Submitted by Deborah Campbell (deborah.campbell@oregonstate.edu) on 2013-04-01T16:44:22Z No. of bitstreams: 1 OddenMichelleCPublicHealthHumanSciencesHypertensionLowHDL.pdf: 188912 bytes, checksum: 6a5f20edb33acc74146f67577e14691e (MD5)
  • description.provenance : Made available in DSpace on 2013-04-01T16:53:30Z (GMT). No. of bitstreams: 1 OddenMichelleCPublicHealthHumanSciencesHypertensionLowHDL.pdf: 188912 bytes, checksum: 6a5f20edb33acc74146f67577e14691e (MD5) Previous issue date: 2013-03
  • description.provenance : Approved for entry into archive by Deborah Campbell(deborah.campbell@oregonstate.edu) on 2013-04-01T16:53:30Z (GMT) No. of bitstreams: 1 OddenMichelleCPublicHealthHumanSciencesHypertensionLowHDL.pdf: 188912 bytes, checksum: 6a5f20edb33acc74146f67577e14691e (MD5)

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