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https://ir.library.oregonstate.edu/concern/articles/k643b306t

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  • Inherent nanomaterial characteristics, composition, surface chemistry, and primary particle size, are known to impact particle stability, uptake, and toxicity. Nanocomposites challenge our ability to predict nanoparticle reactivity in biological systems if they are composed of materials with contrasting relative toxicities. We hypothesized that toxicity would be dominated by the nanoparticle surface (shell vs core), and that modulating the surface ligands would have a direct impact on uptake. We exposed developing zebrafish (Danio rerio) to a series of ~70 nm amine-terminated silver nanoparticles with silica shells (AgSi NPs) to investigate the relative influence of surface amination, composition, and size on toxicity. Like-sized aminated AgSi and Si NPs were more toxic than paired hydroxyl-terminated nanoparticles; however, both AgSi NPs were more toxic than the Si NPs, indicating a significant contribution of the silver core to the toxicity. Incremental increases in surface amination did not linearly increase uptake and toxicity, but did have a marked impact on dispersion stability. Mass-based exposure metrics initially supported the hypothesis that smaller nanoparticles (20 nm) would be more toxic than larger particles (70 nm). However, surface area-based metrics revealed that toxicity was independent of size. Our studies suggest that nanoparticle surfaces play a critical role in the uptake and toxicity of AgSi NPs, while the impact of size may be a function of the exposure metric used. Overall, uptake and toxicity can be dramatically altered by small changes in surface functionalization or exposure media. Only after understanding the magnitude of these changes, can we begin to understand the biologically available dose following nanoparticle exposure.
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  • description.provenance : Made available in DSpace on 2015-04-24T16:34:27Z (GMT). No. of bitstreams: 2 BonventreJosephineEMTImpactAminatedSurface.pdf: 949099 bytes, checksum: 29949a50a4ed30d85780ba41151a9fb6 (MD5) BonventreJosephineEMTImpactAminatedSurface_SupportingInformation.zip: 222513 bytes, checksum: 002505289a2476820694e32ce5d95e2a (MD5) Previous issue date: 2014-12
  • description.provenance : Approved for entry into archive by Erin Clark(erin.clark@oregonstate.edu) on 2015-04-24T16:34:27Z (GMT) No. of bitstreams: 2 BonventreJosephineEMTImpactAminatedSurface.pdf: 949099 bytes, checksum: 29949a50a4ed30d85780ba41151a9fb6 (MD5) BonventreJosephineEMTImpactAminatedSurface_SupportingInformation.zip: 222513 bytes, checksum: 002505289a2476820694e32ce5d95e2a (MD5)
  • description.provenance : Submitted by Erin Clark (erin.clark@oregonstate.edu) on 2015-04-24T16:34:08Z No. of bitstreams: 2 BonventreJosephineEMTImpactAminatedSurface.pdf: 949099 bytes, checksum: 29949a50a4ed30d85780ba41151a9fb6 (MD5) BonventreJosephineEMTImpactAminatedSurface_SupportingInformation.zip: 222513 bytes, checksum: 002505289a2476820694e32ce5d95e2a (MD5)