Article

 

MathewsDeoxyribonucleotideMetabolismMutagenesisAndCancerFigures1-5.pdf Public Deposited

Downloadable Content

Download PDF
https://ir.library.oregonstate.edu/concern/articles/kh04dr390

Descriptions

Attribute NameValues
Creator
Abstract
  • Cancer was recognized as a genetic disease at least four decades ago, with the realization that the spontaneous mutation rate must increase early in tumorigenesis, to account for the many mutations in tumor cells as compared with their progenitor normal cells. The genetic basis for cancer was established also from the finding that viral oncogenes have cellular counterparts, expression of which could transform cells. Deoxyribonucleotide pool abnormalities have long been recognized as determinants of DNA replication fidelity, and hence, may contribute to mutagenic processes involved in carcinogenesis. In addition, many anticancer agents act as antagonists of deoxyribonucleotide metabolism. To what extent may aspects of deoxyribonucleotide metabolism contribute to our understanding of both carcinogenesis and the effective use of anticancer agents?
Keyword
Rights Statement
Additional Information
  • description.provenance : Submitted by Deanne Bruner (deanne.bruner@oregonstate.edu) on 2016-03-10T01:17:21Z No. of bitstreams: 2 MathewsDeoxyribonucleotideMetabolismMutagenesisAndCancer.pdf: 177339 bytes, checksum: 52de941dee30bb1354ca097335b22232 (MD5) MathewsDeoxyribonucleotideMetabolismMutagenesisAndCancerFigures1-5.pdf: 574881 bytes, checksum: 6b9f1538cea6cc5f11ca353a4a6e927a (MD5)
  • description.provenance : Made available in DSpace on 2016-03-10T01:18:59Z (GMT). No. of bitstreams: 2 MathewsDeoxyribonucleotideMetabolismMutagenesisAndCancer.pdf: 177339 bytes, checksum: 52de941dee30bb1354ca097335b22232 (MD5) MathewsDeoxyribonucleotideMetabolismMutagenesisAndCancerFigures1-5.pdf: 574881 bytes, checksum: 6b9f1538cea6cc5f11ca353a4a6e927a (MD5) Previous issue date: 2015-09
  • description.provenance : Approved for entry into archive by Deanne Bruner(deanne.bruner@oregonstate.edu) on 2016-03-10T01:18:59Z (GMT) No. of bitstreams: 2 MathewsDeoxyribonucleotideMetabolismMutagenesisAndCancer.pdf: 177339 bytes, checksum: 52de941dee30bb1354ca097335b22232 (MD5) MathewsDeoxyribonucleotideMetabolismMutagenesisAndCancerFigures1-5.pdf: 574881 bytes, checksum: 6b9f1538cea6cc5f11ca353a4a6e927a (MD5)

Relationships

Parents:

Items