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Regulation of transcription factor activity by interconnected, post-translational modifications Public Deposited

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This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier and can be found at:  http://www.sciencedirect.com/science/journal/01656147.

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Abstract
  • Transcription factors comprise just over 7% of the human proteome and serve as gatekeepers of cellular function, integrating external signal information into gene expression programs that reconfigure cellular physiology at the most basic levels. Surface-initiated cell signaling pathways converge on transcription factors, decorating these proteins with an array of post-translational modifications (PTMs) that are often interdependent, being linked in time, space, and combinatorial function. These PTMs orchestrate every activity of a transcription factor over its entire lifespan—from subcellular localization to protein–protein interactions, sequence-specific DNA binding, transcriptional regulatory activity, and protein stability—and play key roles in the epigenetic regulation of gene expression. The multitude of PTMs of transcription factors also offers numerous potential points of intervention for development of therapeutic agents to treat a wide spectrum of diseases. We review PTMs most commonly targeting transcription factors, focusing on recent reports of sequential and linked PTMs of individual factors.
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  • Filtz, T. M., Vogel, W. K., & Leid, M. (2014). Regulation of transcription factor activity by interconnected post-translational modifications. Trends in Pharmacological Sciences, 35(2), 76-85. doi:10.1016/j.tips.2013.11.005
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  • 35
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  • 2
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  • This work was supported in part by the National Institutes of General Medical Sciences (grant GM096243 to T.M.F.) and Dental and Craniofacial Research (grant DE021879 to M.L.) of the National Institutes of Health.
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  • description.provenance : Approved for entry into archive by Erin Clark(erin.clark@oregonstate.edu) on 2014-07-10T16:16:23Z (GMT) No. of bitstreams: 1 FiltzTheresaPharmacyRegulationTranscriptionFactor.pdf: 3555635 bytes, checksum: 4a24a9959a6550f0f7d1d0bea214198d (MD5)
  • description.provenance : Submitted by Erin Clark (erin.clark@oregonstate.edu) on 2014-07-10T16:16:02Z No. of bitstreams: 1 FiltzTheresaPharmacyRegulationTranscriptionFactor.pdf: 3555635 bytes, checksum: 4a24a9959a6550f0f7d1d0bea214198d (MD5)
  • description.provenance : Made available in DSpace on 2014-07-10T16:16:23Z (GMT). No. of bitstreams: 1 FiltzTheresaPharmacyRegulationTranscriptionFactor.pdf: 3555635 bytes, checksum: 4a24a9959a6550f0f7d1d0bea214198d (MD5) Previous issue date: 2014-02

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