Estimating effects of arsenic exposure during pregnancy on perinatal outcomes in a Bangladeshi cohort Public Deposited

http://ir.library.oregonstate.edu/concern/articles/ns064b56p

The published article is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.

This is a non-final version of an article published in final form in "Kile, M. L., Cardenas, A., Rodrigues, E., Mazumdar, M., Dobson, C., Golam, M., ... & Christiani, D. C. (2016). Estimating effects of arsenic exposure during pregnancy on perinatal outcomes in a Bangladeshi cohort. Epidemiology, 27(2), 173-181. doi:10.1097/EDE.0000000000000416." The published article is copyrighted by Wolters Kluwer Health, Inc. and can be found at:  http://journals.lww.com/epidem/Pages/default.aspx

Descriptions

Attribute NameValues
Alternative Title
  • Estimating direct and indirect effects of arsenic exposure during pregnancy on maternal weight gain, gestational age, and birth weight in a Bangladeshi birth cohort
Creator
Abstract or Summary
  • BACKGROUND: The relationship between arsenic and birth weight is not well understood. OBJECTIVE: To evaluate the causal relationship between prenatal arsenic exposure and birth weight considering the potential mediation effects of gestational age (GA) and maternal weight gain (MWG) during pregnancy using structural equation models (SEMs). METHODS: A prospectively enrolled cohort of pregnant women was recruited in Bangladesh from 2008-2011. Arsenic was measured in personal drinking water at the time of enrollment (<16 GA, N=1,140) and in toenails collected ≤1 month postpartum (N=624) using inductively coupled plasma mass spectrometry. SEMs estimated the direct and indirect effects of arsenic on birth weight with GA and MWG considered as mediating variables. RESULTS: Every unit increase in natural log water arsenic was indirectly associated with decreased birth weight (β=-19.17 grams, 95% CI: -24.64, -13.69) after adjusting for other risk factors. This association was mediated entirely through GA (β=-17.37 grams, 95% CI: -22.77, -11.98) and MWG during pregnancy (β=-1.80 grams, 95% CI: -3.72, 0.13). When exposure was modeled using toenail arsenic concentrations, similar results were observed. Every increase in natural log toenail arsenic was indirectly associated with decreased birth weight (β=-15.72 grams, 95% CI: -24.52, -6.91) which was mediated through GA (β=-13.59 grams, 95% CI: -22.10, -5.07) and MWG during pregnancy (β=-2.13grams, 95% CI: -5.24, 0.96). CONCLUSION: Arsenic exposure during pregnancy was associated with lower birth weight. The effect of arsenic on birth weight appears to be mediated mainly through decreasing gestational age and to a lesser extent by lower maternal weight gain during pregnancy.
Resource Type
DOI
Date Available
Date Issued
Citation
  • Kile, M. L., Cardenas, A., Rodrigues, E., Mazumdar, M., Dobson, C., Golam, M., ... & Christiani, D. C. (2016). Estimating effects of arsenic exposure during pregnancy on perinatal outcomes in a Bangladeshi cohort. Epidemiology, 27(2), 173-181. doi:10.1097/EDE.0000000000000416
Series
Rights Statement
Funding Statement (additional comments about funding)
Publisher
Peer Reviewed
Language
Replaces

Relationships

In Administrative Set:
Last modified: 01/07/2016

Downloadable Content

Download PDF
Citations:

EndNote | Zotero | Mendeley

Items