Development of a Whole Blood Paper-Based Device for Phenylalanine Detection in the Context of PKU Therapy Monitoring Public Deposited

http://ir.library.oregonstate.edu/concern/articles/p2676x09h

This is the publisher’s final pdf. The published article is copyrighted by the author(s) and published by MDPI. The published article can be found at:  http://www.mdpi.com/journal/micromachines

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • Laboratory-based testing does not allow for the sufficiently rapid return of data to enable optimal therapeutic monitoring of patients with metabolic diseases such as phenylketonuria (PKU). The typical turn-around time of several days for current laboratory-based testing is too slow to be practically useful for effective monitoring or optimizing therapy. This report describes the development of a rapid, paper-based, point-of-care device for phenylalanine detection using a small volume (40 μL) of whole blood. The quantitative resolution and reproducibility of this device with instrumented readout are described, together with the potential use of this device for point-of-care monitoring by PKU patients.
Resource Type
DOI
Date Available
Date Issued
Citation
  • Robinson, R., Wong, L., Monnat Jr., R. J., & Fu, E. (2016). Development of a Whole Blood Paper-Based Device for Phenylalanine Detection in the Context of PKU Therapy Monitoring. Micromachines, 7(2), UNSP 28. doi:10.3390/mi7020028
Series
Keyword
Rights Statement
Funding Statement (additional comments about funding)
Publisher
Peer Reviewed
Language
Replaces
Additional Information
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2016-04-11T18:05:18Z (GMT) No. of bitstreams: 2 license_rdf: 1370 bytes, checksum: cd1af5ab51bcc7a5280cf305303530e9 (MD5) RobinsonDevelopmentWholeBlood.pdf: 1705981 bytes, checksum: 5eb3e8bdf970767ed79115e0cbdeaa9a (MD5)
  • description.provenance : Made available in DSpace on 2016-04-11T18:05:18Z (GMT). No. of bitstreams: 2 license_rdf: 1370 bytes, checksum: cd1af5ab51bcc7a5280cf305303530e9 (MD5) RobinsonDevelopmentWholeBlood.pdf: 1705981 bytes, checksum: 5eb3e8bdf970767ed79115e0cbdeaa9a (MD5) Previous issue date: 2016-02
  • description.provenance : Submitted by Patricia Black (patricia.black@oregonstate.edu) on 2016-04-11T18:04:56Z No. of bitstreams: 2 license_rdf: 1370 bytes, checksum: cd1af5ab51bcc7a5280cf305303530e9 (MD5) RobinsonDevelopmentWholeBlood.pdf: 1705981 bytes, checksum: 5eb3e8bdf970767ed79115e0cbdeaa9a (MD5)

Relationships

Parents:

This work has no parents.

Last modified

Downloadable Content

Download PDF

Items