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Development of a Whole Blood Paper-Based Device for Phenylalanine Detection in the Context of PKU Therapy Monitoring

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https://ir.library.oregonstate.edu/concern/articles/p2676x09h

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Abstract
  • Laboratory-based testing does not allow for the sufficiently rapid return of data to enable optimal therapeutic monitoring of patients with metabolic diseases such as phenylketonuria (PKU). The typical turn-around time of several days for current laboratory-based testing is too slow to be practically useful for effective monitoring or optimizing therapy. This report describes the development of a rapid, paper-based, point-of-care device for phenylalanine detection using a small volume (40 μL) of whole blood. The quantitative resolution and reproducibility of this device with instrumented readout are described, together with the potential use of this device for point-of-care monitoring by PKU patients.
  • Keywords: whole-blood assay, phenylketonuria, phenylalanine detection, colorimetric readout, paper-based device
  • Keywords: whole-blood assay, phenylketonuria, phenylalanine detection, colorimetric readout, paper-based device
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  • Robinson, R., Wong, L., Monnat Jr., R. J., & Fu, E. (2016). Development of a Whole Blood Paper-Based Device for Phenylalanine Detection in the Context of PKU Therapy Monitoring. Micromachines, 7(2), UNSP 28. doi:10.3390/mi7020028
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  • 7
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  • 2
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  • The research reported in this publication was supported by funds from the National PKU Alliance and from Oregon State University.
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