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A cross sectional study of anemia and iron deficiency as risk factors for arsenic-induced skin lesions in Bangladeshi women Public Deposited

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  • Background: In the Ganges Delta, chronic arsenic poisoning is a health concern affecting millions of people who rely on groundwater as their potable water source. The prevalence of anemia is also high in this region, particularly among women. Moreover, arsenic is known to affect heme synthesis and erythrocytes and the risk of arsenic-induced skin lesions appears to differ by sex. Methods: We conducted a case-control study in 147 arsenic-exposed Bangladeshi women to assess the association between anemia and arsenic-induced skin lesions. Results: We observed that the odds of arsenic-related skin lesions were approximately three times higher among women who were anemic (hemoglobin < 120 g/L) compared to women with normal hemoglobin levels [Odds Ratio (OR) = 3.32, 95 % Confidence Intervals (CI): 1.29, 8.52] after adjusting for arsenic levels in drinking water and other covariates. Furthermore, 75 % of the women with anemia had adequate iron stores (serum ferritin ≥12 μg/L), suggesting that the majority of anemia detected in this population was unrelated to iron depletion. Conclusions: Considering the magnitude of arsenic exposure and prevalence of anemia in Bangladeshi women, additional research is warranted that identifies the causes of anemia so that effective interventions can be implemented while arsenic remediation efforts continue.
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  • Kile, M. L., Faraj, J. M., Ronnenberg, A. G., Quamruzzaman, Q., Rahman, M., Mostofa, G., ... & Christiani, D. C. (2016). A cross sectional study of anemia and iron deficiency as risk factors for arsenic-induced skin lesions in Bangladeshi women. BMC Public Health, 16, 158. doi:10.1186/s12889-016-2824-4
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  • This research was funded by the National Institute of Environmental Health Sciences (NIEHS) grants R01 ES011622, P42 ES005947, P42 ES016454, K01 ES017800, P30 ES00002, and P30 ES000210. Funds were also supplied by the Department of Nutrition at the University of Massachusetts, Amherst.
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  • description.provenance : Submitted by Patricia Black (patricia.black@oregonstate.edu) on 2016-03-16T16:22:57Z No. of bitstreams: 2 license_rdf: 1370 bytes, checksum: cd1af5ab51bcc7a5280cf305303530e9 (MD5) KileCrossSectionalStudyAnemia.pdf: 517083 bytes, checksum: 34ae475070656a42a83f1586556a7780 (MD5)
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