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Shadow Enhancers as a Source of Evolutionary Novelty Public Deposited

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https://ir.library.oregonstate.edu/concern/articles/r781wg84m

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  • The dorsal-ventral patterning of the Drosophila embryo is controlled by Dorsal, a sequence-specific transcription factor that is related to mammalian NF-κB. Previous ChIP-chip assays predicted that as many as a third or even half of all Dorsal target genes contain multiple enhancers for the same or similar expression pattern. Here we show that some of these secondary enhancers, or “shadow enhancers”, produce gene expression patterns that overlap those produced by the primary enhancers in transgenic embryos. We suggest that shadow enhancers help ensure the precision of embryonic patterning and discuss their significance in the evolution of genetic novelty.
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  • Hong, J. W., Hendrix, D. A., & Levine, M. S. (2008). Shadow enhancers as a source of evolutionary novelty. Science, 321(5894), 1314. doi:10.1126/science.1160631
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  • 321
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  • 5894
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  • This study was funded by the NIH (GM46638) and Moore Foundation.
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  • description.provenance : Approved for entry into archive by Erin Clark(erin.clark@oregonstate.edu) on 2014-06-30T21:06:12Z (GMT) No. of bitstreams: 1 HendrixDavidBiochemistryBiophysicsShadowEnhancers.pdf: 30961 bytes, checksum: 2b9ac59e943a252753d3cd152c0946d9 (MD5)
  • description.provenance : Submitted by Erin Clark (erin.clark@oregonstate.edu) on 2014-06-30T21:05:46Z No. of bitstreams: 1 HendrixDavidBiochemistryBiophysicsShadowEnhancers.pdf: 30961 bytes, checksum: 2b9ac59e943a252753d3cd152c0946d9 (MD5)
  • description.provenance : Made available in DSpace on 2014-06-30T21:06:12Z (GMT). No. of bitstreams: 1 HendrixDavidBiochemistryBiophysicsShadowEnhancers.pdf: 30961 bytes, checksum: 2b9ac59e943a252753d3cd152c0946d9 (MD5) Previous issue date: 2008-09-05

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