Article

 

BissonWilliamHEnvironmentalMolecularToxicologyPotentialChemicalMixtures.pdf Public Deposited

Downloadable Content

Download PDF
https://ir.library.oregonstate.edu/concern/articles/rb68xd63k

Descriptions

Attribute NameValues
Creator
Abstract
  • The aim of this work is to review current knowledge relating the established cancer hallmark, sustained cell proliferation to the existence of chemicals present as low dose mixtures in the environment. Normal cell proliferation is under tight control, i.e. cells respond to a signal to proliferate, and although most cells continue to proliferate into adult life, the multiplication ceases once the stimulatory signal disappears or if the cells are exposed to growth inhibitory signals. Under such circumstances, normal cells remain quiescent until they are stimulated to resume further proliferation. In contrast, tumour cells are unable to halt proliferation, either when subjected to growth inhibitory signals or in the absence of growth stimulatory signals. Environmental chemicals with carcinogenic potential may cause sustained cell proliferation by interfering with some cell proliferation control mechanisms committing cells to an indefinite proliferative span.
Rights Statement
Additional Information
  • description.provenance : Made available in DSpace on 2015-07-15T17:44:17Z (GMT). No. of bitstreams: 2 BissonWilliamHEnvironmentalMolecularToxicologyPotentialChemicalMixtures.pdf: 2524390 bytes, checksum: a0e91400c4aadfa872d38e66c855e21b (MD5) BissonWilliamHEnvironmentalMolecularToxicologyPotentialChemicalMixturesSupplementaryTables.pdf: 183430 bytes, checksum: ede439b4467a85063c3d513002b0aff6 (MD5) Previous issue date: 2015-06
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2015-07-15T17:44:17Z (GMT) No. of bitstreams: 2 BissonWilliamHEnvironmentalMolecularToxicologyPotentialChemicalMixtures.pdf: 2524390 bytes, checksum: a0e91400c4aadfa872d38e66c855e21b (MD5) BissonWilliamHEnvironmentalMolecularToxicologyPotentialChemicalMixturesSupplementaryTables.pdf: 183430 bytes, checksum: ede439b4467a85063c3d513002b0aff6 (MD5)
  • description.provenance : Submitted by Patricia Black (patricia.black@oregonstate.edu) on 2015-07-15T16:31:45Z No. of bitstreams: 2 BissonWilliamHEnvironmentalMolecularToxicologyPotentialChemicalMixtures.pdf: 2524390 bytes, checksum: a0e91400c4aadfa872d38e66c855e21b (MD5) BissonWilliamHEnvironmentalMolecularToxicologyPotentialChemicalMixturesSupplementaryTables.pdf: 183430 bytes, checksum: ede439b4467a85063c3d513002b0aff6 (MD5)