Proteomics of Neisseria gonorrhoeae: the treasure hunt for countermeasures against an old disease Public Deposited

http://ir.library.oregonstate.edu/concern/articles/rf55z936x

This is the publisher’s final pdf. The published article is copyrighted by the author(s) and published by the Frontiers Research Foundation. The published article can be found at:  http://journal.frontiersin.org/journal/microbiology

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • Neisseria gonorrhoeae is an exquisitely adapted, strictly human pathogen and the causative agent of the sexually transmitted infection gonorrhea. This ancient human disease remains a serious problem, occurring at high incidence globally and having a major impact on reproductive and neonatal health. N. gonorrhoeae is rapidly evolving into a superbug and no effective vaccine exists to prevent gonococcal infections. Untreated or inadequately treated gonorrhea can lead to severe sequelae, including pelvic inflammatory disease and infertility in women, epididymitis in men, and sight-threatening conjunctivitis in infants born to infected mothers. Therefore, there is an immediate need for accelerated research toward the identification of molecular targets for development of drugs with new mechanisms of action and preventive vaccine(s). Global proteomic approaches are ideally suited to guide these studies. Recent quantitative proteomics (SILAC, iTRAQ, and ICAT) have illuminated the pathways utilized by N. gonorrhoeae to adapt to different lifestyles and micro-ecological niches within the host, while comparative 2D SDS-PAGE analysis has been used to elucidate spectinomycin resistance mechanisms. Further, high-throughput examinations of cell envelopes and naturally released membrane vesicles have unveiled the ubiquitous and differentially expressed proteins between temporally and geographically diverse N. gonorrhoeae isolates. This review will focus on these different approaches, emphasizing the role of proteomics in the search for vaccine candidates. Although our knowledge of N. gonorrhoeae has been expanded, still far less is known about this bacterium than the closely related N. meningitidis, where genomics- and proteomics-driven studies have led to the successful development of vaccines.
Resource Type
DOI
Date Available
Date Issued
Citation
  • Baarda, B. I., & Sikora, A. E. (2015). Proteomics of Neisseria gonorrhoeae: the treasure hunt for countermeasures against an old disease. Frontiers in Microbiology, 6, 1190. doi:10.3389/fmicb.2015.01190
Series
Keyword
Rights Statement
Funding Statement (additional comments about funding)
Publisher
Peer Reviewed
Language
Replaces
Additional Information
  • description.provenance : Made available in DSpace on 2015-12-08T15:56:23Z (GMT). No. of bitstreams: 2 license_rdf: 1370 bytes, checksum: cd1af5ab51bcc7a5280cf305303530e9 (MD5) BaardaBenjaminPharmProteomicsNeisseriaGonorrhoeae.pdf: 1922473 bytes, checksum: c251fed77c81a2ebfbdd72fcdacc2752 (MD5) Previous issue date: 2015-10-26
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2015-12-08T15:56:23Z (GMT) No. of bitstreams: 2 license_rdf: 1370 bytes, checksum: cd1af5ab51bcc7a5280cf305303530e9 (MD5) BaardaBenjaminPharmProteomicsNeisseriaGonorrhoeae.pdf: 1922473 bytes, checksum: c251fed77c81a2ebfbdd72fcdacc2752 (MD5)
  • description.provenance : Submitted by Patricia Black (patricia.black@oregonstate.edu) on 2015-12-08T15:55:26Z No. of bitstreams: 2 license_rdf: 1370 bytes, checksum: cd1af5ab51bcc7a5280cf305303530e9 (MD5) BaardaBenjaminPharmProteomicsNeisseriaGonorrhoeae.pdf: 1922473 bytes, checksum: c251fed77c81a2ebfbdd72fcdacc2752 (MD5)

Relationships

In Administrative Set:
Last modified: 07/26/2017

Downloadable Content

Download PDF
Citations:

EndNote | Zotero | Mendeley

Items