Early life perfluorooctanesulphonic acid (PFOS) exposure impairs zebrafish organogenesis Public Deposited

http://ir.library.oregonstate.edu/concern/articles/t722hb747

Additional authors (Zengxin Gai and Xue Ma) appear and the author order is revised on the published version of this article.

This is an author's peer-reviewed manuscript. The published article is copyrighted by Elsevier and can be found at:  http://www.journals.elsevier.com/aquatic-toxicology/.

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  • As a persistent organic contaminant, perfluorooctanesulphonic acid (PFOS) has been widely detected in the environment, wildlife, and humans. The present study revealed that zebrafish embryos exposed to 16 µM PFOS during a sensitive window of 48-96 hour post-fertilization (hpf) disrupted larval morphology at 120 hpf. Malformed zebrafish larvae were characterized by uninflated swim bladder, less developed gut, and curved spine. Histological and ultrastructural examination of PFOS-exposed larvae showed structural alterations in swim bladder and gut. Whole genome microarray was used to identify the early transcripts dysregulated following exposure to 16 µM PFOS at 96 hpf. In total, 1,278 transcripts were significantly misexpressed (p < 0.05) and 211 genes were changed at least two-fold upon PFOS exposure in comparison to the vehicle exposed control group. A PFOS-induced network of perturbed transcripts relating to swim bladder and gut development revealed that misexpression of genes were involved in organogenesis. Taken together, early life stage exposure to PFOS perturbs various molecular pathways potentially resulting in observed defects in swim bladder and gut development.
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  • Chen, J., Tanguay, R. L., Tal, T. L., Gai, Z., Ma, X., Bai, C., ... & Dong, Q. (2014). Early life perfluorooctanesulphonic acid (PFOS) exposure impairs zebrafish organogenesis. Aquatic Toxicology, 150, 124-132. doi:10.1016/j.aquatox.2014.03.005
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  • description.provenance : Made available in DSpace on 2014-08-13T18:32:43Z (GMT). No. of bitstreams: 2 TanguayRobertEnvironmentalMolecularToxicologyEarlyLifePerfluorooctanesulphonic.pdf: 1108714 bytes, checksum: 172e2219b37bb31f469bba03f1b403d0 (MD5) TanguayRobertEnvironmentalMolecularToxicologyEarlyLifePerfluorooctanesulphonic(Figures).pdf: 3305174 bytes, checksum: ca744569ae3208a7356bbf284900c68f (MD5) Previous issue date: 2014-05
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  • description.provenance : Submitted by Deanne Bruner (deanne.bruner@oregonstate.edu) on 2014-08-13T18:31:34Z No. of bitstreams: 2 TanguayRobertEnvironmentalMolecularToxicologyEarlyLifePerfluorooctanesulphonic.pdf: 1108714 bytes, checksum: 172e2219b37bb31f469bba03f1b403d0 (MD5) TanguayRobertEnvironmentalMolecularToxicologyEarlyLifePerfluorooctanesulphonic(Figures).pdf: 3305174 bytes, checksum: ca744569ae3208a7356bbf284900c68f (MD5)

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