Article
 

Early life perfluorooctanesulphonic acid (PFOS) exposure impairs zebrafish organogenesis

Public Deposited

Contenu téléchargeable

Télécharger le fichier PDF
https://ir.library.oregonstate.edu/concern/articles/t722hb747

Descriptions

Attribute NameValues
Creator
Abstract
  • Additional authors (Zengxin Gai and Xue Ma) appear and the author order is revised on the published version of this article.
  • As a persistent organic contaminant, perfluorooctanesulphonic acid (PFOS) has been widely detected in the environment, wildlife, and humans. The present study revealed that zebrafish embryos exposed to 16 µM PFOS during a sensitive window of 48-96 hour post-fertilization (hpf) disrupted larval morphology at 120 hpf. Malformed zebrafish larvae were characterized by uninflated swim bladder, less developed gut, and curved spine. Histological and ultrastructural examination of PFOS-exposed larvae showed structural alterations in swim bladder and gut. Whole genome microarray was used to identify the early transcripts dysregulated following exposure to 16 µM PFOS at 96 hpf. In total, 1,278 transcripts were significantly misexpressed (p < 0.05) and 211 genes were changed at least two-fold upon PFOS exposure in comparison to the vehicle exposed control group. A PFOS-induced network of perturbed transcripts relating to swim bladder and gut development revealed that misexpression of genes were involved in organogenesis. Taken together, early life stage exposure to PFOS perturbs various molecular pathways potentially resulting in observed defects in swim bladder and gut development.
  • This is an author's peer-reviewed manuscript. The published article is copyrighted by Elsevier and can be found at: http://www.journals.elsevier.com/aquatic-toxicology/.
  • Keywords: Perfluorooctanesulfonic acid, Zebrafish embryo, Developmental toxicity, Swim bladder, Gut
  • Keywords: Perfluorooctanesulfonic acid, Zebrafish embryo, Developmental toxicity, Swim bladder, Gut
Resource Type
DOI
Date Available
Date Issued
Citation
  • Chen, J., Tanguay, R. L., Tal, T. L., Gai, Z., Ma, X., Bai, C., ... & Dong, Q. (2014). Early life perfluorooctanesulphonic acid (PFOS) exposure impairs zebrafish organogenesis. Aquatic Toxicology, 150, 124-132. doi:10.1016/j.aquatox.2014.03.005
Journal Title
Journal Volume
  • 150
Déclaration de droits
Funding Statement (additional comments about funding)
  • This work was supported by funding from the National Natural Science Foundation of China (No. 21277104), the Key Project of Zhejiang Provincial Natural Science Foundation (LZ13B070001), and the National Institute of Environmental Health Sciences grants #P30 ES00210 and P42 ES016465.
Publisher
Peer Reviewed
Language
Replaces

Des relations

Parents:

This work has no parents.

Articles

La vignette Titre Date de téléchargement Visibilité actes
file details TanguayRobertEnvironmentalMolecularToxicologyEarlyLifePerfluorooctanesulphonic.pdf 07/26/2017 Public
file details TanguayRobertEnvironmentalMolecularToxicologyEarlyLifePerfluorooctanesulphonic(Figures).pdf 07/26/2017 Public