Innate and adaptive immune responses in migrating spring-run adult chinook salmon, Oncorhynchus tshawytscha Public Deposited

http://ir.library.oregonstate.edu/concern/articles/tx31qk46w

To the best of our knowledge, one or more authors of this paper were federal employees when contributing to this work. This is the publisher’s final pdf. The published article is copyrighted by Elsevier and can be found at:  http://www.journals.elsevier.com/fish-and-shellfish-immunology/

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • Adult Chinook salmon (Oncorhynchus tshawytscha) migrate from salt water to freshwater streams to spawn. Immune responses in migrating adult salmon are thought to diminish in the run up to spawning, though the exact mechanisms for diminished immune responses remain unknown. Here we examine both adaptive and innate immune responses as well as pathogen burdens in migrating adult Chinook salmon in the Upper Willamette River basin. Messenger RNA transcripts encoding antibody heavy chain molecules slightly diminish as a function of time, but are still present even after fish have successfully spawned. In contrast, the innate anti-bacterial effector proteins present in fish plasma rapidly decrease as spawning approaches. Fish also were examined for the presence and severity of eight different pathogens in different organs. While pathogen burden tended to increase during the migration, no specific pathogen signature was associated with diminished immune responses. Transcript levels of the immunosuppressive cytokines IL-10 and TGF beta were measured and did not change during the migration. These results suggest that loss of immune functions in adult migrating salmon are not due to pathogen infection or cytokine-mediated immune suppression, but is rather part of the life history of Chinook salmon likely induced by diminished energy reserves or hormonal changes which accompany spawning.
Resource Type
DOI
Date Available
Date Issued
Citation
  • Dolan, B. P., Fisher, K. M., Colvin, M. E., Benda, S. E., Peterson, J. T., Kent, M. L., & Schreck, C. B. (2016). Innate and adaptive immune responses in migrating spring-run adult chinook salmon, Oncorhynchus tshawytscha. Fish & Shellfish Immunology, 48, 136-144. doi:10.1016/j.fsi.2015.11.015
Series
Keyword
Rights Statement
Funding Statement (additional comments about funding)
Publisher
Peer Reviewed
Language
Replaces
Additional Information
  • description.provenance : Submitted by Patricia Black (patricia.black@oregonstate.edu) on 2016-03-01T16:00:55Z No. of bitstreams: 1 DolanBrianVetMedInnateAdaptiveImmune.pdf: 1572956 bytes, checksum: e718c5122fe3e86dc42d5fc88b0ec3a1 (MD5)
  • description.provenance : Made available in DSpace on 2016-03-01T16:01:31Z (GMT). No. of bitstreams: 1 DolanBrianVetMedInnateAdaptiveImmune.pdf: 1572956 bytes, checksum: e718c5122fe3e86dc42d5fc88b0ec3a1 (MD5) Previous issue date: 2016-01
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2016-03-01T16:01:31Z (GMT) No. of bitstreams: 1 DolanBrianVetMedInnateAdaptiveImmune.pdf: 1572956 bytes, checksum: e718c5122fe3e86dc42d5fc88b0ec3a1 (MD5)

Relationships

Parents:

This work has no parents.

Last modified

Downloadable Content

Download PDF

Items