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Bisphenol A Exposure During Early Development Induces Sex-Specific Changes in Adult Zebrafish Social Interactions

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https://ir.library.oregonstate.edu/concern/articles/vd66w484g

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  • Developmental bisphenol A (BPA) exposure is associated with adverse behavioral effects, although underlying modes of action remain unclear. Because BPA is a suspected xenoestrogen, the objective was to identify sex-based changes in adult zebrafish social behavior developmentally exposed to BPA (0.0, 0.1 or 1 μM) or one of two control compounds (0.1 μM 17β-estradiol [E2], and 0.1 μM GSK4716, a synthetic estrogen-related receptor γ ligand). A test chamber was divided lengthwise so each arena held one fish unable to detect the presence of the other fish. A mirror was inserted at one end of each arena; baseline activity levels were determined without mirror. Arenas were divided into 3, computer-generated zones to represent different distances from mirror image. Circadian rhythm patterns were evaluated at 1-3 (= AM) and 5-8 (= PM) hr postprandial. Adult zebrafish were placed into arenas and monitored by digital camera for 5 min. Total distance traveled, % time spent at mirror image, and number of attacks on mirror image were quantified. E2, GSK4716, and all BPA treatments dampened male activity and altered male circadian activity patterns; there was no marked effect on female activity. BPA induced non-monotonic effects (response curve changes direction within range of concentrations examined) on male % time at mirror only in AM. All treatments produced increased % time at the mirror during PM. Male attacks on the mirror were reduced by BPA exposure only during AM. There were sex-specific effects of developmental BPA on social interactions and time-of-day of observation affected results.
  • Keywords: social behavior, bisphenol A, agonistic behavior, developmental exposure, zebrafish, circadian rhythms, sex-specific behavior
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  • Weber, D. N., Hoffmann, R. G., Hoke, E. S., & Tanguay, R. L. (2015). Bisphenol A Exposure During Early Development Induces Sex-Specific Changes in Adult Zebrafish Social Interactions. Journal of Toxicology and Environmental Health, Part A, 78(1), 50-66. doi:10.1080/15287394.2015.958419
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  • 78
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  • 1
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  • This research was supported by NIEHS grants ES04184 (to D.H. Petering with Core Center Pilot Project funding to D.N. Weber), and ES018970 and ES000210 (both to R.L. Tanguay).
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