Hyperdiverse Gene Cluster in Snail Host Conveys Resistance to Human Schistosome Parasites Public Deposited

http://ir.library.oregonstate.edu/concern/articles/w37638498

This is the publisher’s final pdf. The published article is copyrighted by the author(s) and published by the Public Library of Science. The published article can be found at:  http://journals.plos.org/plosgenetics/. Supporting information can be found at:  http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005067#sec024

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  • Schistosomiasis, a neglected global pandemic, may be curtailed by blocking transmission of the parasite via its intermediate hosts, aquatic snails. Elucidating the genetic basis of snail-schistosome interaction is a key to this strategy. Here we map a natural parasite-resistance polymorphism from a Caribbean population of the snail Biomphalaria glabrata. In independent experimental evolution lines, RAD genotyping shows that the same genomic region responds to selection for resistance to the parasite Schistosoma mansoni. A dominant allele in this region conveys an 8-fold decrease in the odds of infection. Fine-mapping and RNA-Seq characterization reveal a <1Mb region, the Guadeloupe Resistance Complex (GRC), with 15 coding genes. Seven genes are single-pass transmembrane proteins with putative immunological roles, most of which show strikingly high nonsynonymous divergence (5-10%) among alleles. High linkage disequilibrium among three intermediate-frequency (>25%) haplotypes across the GRC, a significantly non-neutral pattern, suggests that balancing selection maintains diversity at the GRC. Thus, the GRC resembles immune gene complexes seen in other taxa and is likely involved in parasite recognition. The GRC is a potential target for controlling transmission of schistosomiasis, including via genetic manipulation of snails.
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  • Tennessen, J. A., Théron, A., Marine, M., Yeh, J. Y., Rognon, A., & Blouin, M. S. (2015). Hyperdiverse Gene Cluster in Snail Host Conveys Resistance to Human Schistosome Parasites. PLoS Genetics, 11(3), e1005067. doi:10.1371/journal.pgen.1005067
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  • description.provenance : Made available in DSpace on 2015-05-14T23:05:54Z (GMT). No. of bitstreams: 2 license_rdf: 1370 bytes, checksum: cd1af5ab51bcc7a5280cf305303530e9 (MD5) TennessenJacobIntegrativeBiologyHyperdiverseGeneCluster.pdf: 841172 bytes, checksum: 6cda4a8bb6f810c1215edd2357413791 (MD5) Previous issue date: 2015-03-16
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  • description.provenance : Approved for entry into archive by Erin Clark(erin.clark@oregonstate.edu) on 2015-05-14T23:05:54Z (GMT) No. of bitstreams: 2 license_rdf: 1370 bytes, checksum: cd1af5ab51bcc7a5280cf305303530e9 (MD5) TennessenJacobIntegrativeBiologyHyperdiverseGeneCluster.pdf: 841172 bytes, checksum: 6cda4a8bb6f810c1215edd2357413791 (MD5)

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