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Lespedeza davurica (Lax.) Schindl. Extract Protects against Cytokine-Induced đť›˝-Cell Damage and Streptozotocin-Induced Diabetes

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https://ir.library.oregonstate.edu/concern/articles/xd07gx915

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  • This is the publisher’s final pdf. The published article is copyrighted by the author(s) and published by the Hindawi Publishing Corporation. The published article can be found at: http://dx.doi.org/10.1155/2015/169256
  • Lespedeza has been used for the management of diabetes in folklore medicine. The purpose of this study is to investigate the protective effects of the methanol extract of Lespedeza davurica (LD) on cytokine-induced đť›˝-cell damage and streptozotocin- (STZ-) induced diabetes. RINm5F cells were treated with interleukin- (IL-) 1đť›˝ and interferon- (IFN-) 𝛾 to induce pancreatic đť›˝-cell damage. The exposure of LD extract significantly decreased cell death, nitric oxide (NO) production, nitric oxide synthase (iNOS) expression, and nucleus factor-kappa B (NF-đťś…B) p65 activation. Antidiabetic effects of LD extract were observed by oral glucose tolerance test (OGTT) in normal rats and by checking the biochemical, physiological, and histopathological parameters in STZ-induced diabetic rats. In OGTT, glucose clearance levels improved by oral treatment of LD extract. The water intake, urine volume, blood glucose, and serum TG, TC, TBARS, and DPP-IV levels were significantly decreased, and liver glycogen content was significantly increased by treatment of LD extract (250 mg/kg BW) in STZ-induced diabetic rats. Also, insulin immunoreactivity of the pancreases was increased in LD extract administrated rats compared with diabetic control rats. These results indicate that LD extract may protect pancreatic đť›˝-cell damage and regulate the blood glucose in STZ-induced diabetic rats.
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  • Sharma, B. R., & Rhyu, D. Y. (2015). Lespedeza davurica (Lax.) Schindl. Extract Protects against Cytokine-Induced β-Cell Damage and Streptozotocin-Induced Diabetes. BioMed Research International, 169256. doi:10.1155/2015/169256
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  • 2015
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  • 169256
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  • This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science, and Technology (NRF-2009-0077541).
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