Article

 

Analysis of stress factors associated with KHV reactivation and pathological effects from KHV reactivation Public Deposited

Default
https://ir.library.oregonstate.edu/concern/articles/xs55mj357

Descriptions

Attribute NameValues
Alternative Title
Creator
Abstract
  • Koi herpesvirus (KHV) is a highly pathogenic virus of common carp and koi. KHV becomes latent in recovered koi or exposed koi without symptoms, and the latent infection can reactivate under stress conditions. KHV reactivation from latency often occurs when water temperature rapidly rises above 17 °C. Dissolved O2 is lower at ≥17 °C than at non-stress temperatures ≤15 °C. To determine whether reduced dissolved O2 level has a role in KHV reactivation during temperature stress, KHV reactivation was investigated in KHV latently infected koi (KHV+ koi) under stress temperatures by maintaining dissolved O2 consistent with the O2 level at 15 °C. There was no significant difference in the amount of reactivated virus between KHV+ koi maintained with and without O2 supplementation during temperature stress. Both handling and sampling were found to be stressful to koi and can contribute to KHV reactivation from latency. There was an increase in KHV genome within white blood cells (WBC) during KHV reactivation, which is about 3–4 fold higher than the amount of KHV genome detectable in WBC during the latency stage. At day 15 post-temperature stress (PTS), inflammation and necrosis were observed in multiple tissues, especially in the gills, eye, intestine, skin and kidney. KHV DNA was also detectable in multiple tissues on days 6, 9 and 15 PTS. Following day 3 PTS, the plasma cortisol levels were higher than that observed in koi before temperature stress, suggesting that KHV reactivation is associated with physiological stress in KHV+ koi.
License
Resource Type
DOI
Date Issued
Citation
  • Lin, L., Chen, S., Russell, D.S., Löhr, C.V., Milston-Clements, R., Song, T., Miller-Morgan, T., Jin, L., 2017. Analysis of stress factors associated with KHV reactivation and pathological effects from KHV reactivation. Virus Research 240, 200–206. https://doi.org/10.1016/j.virusres.2017.08.010
Journal Title
Journal Volume
  • 240
Academic Affiliation
Non-Academic Affiliation
Rights Statement
Related Items
Publisher
Peer Reviewed
Language
Additional Information
  • To access this item from the National Sea Grant Library via interlibrary loan, email a request to nsgl[at]gso.uri.edu. Include article title, author, year published, and ORESU number.

Relationships

Parents:
In Collection:

Items