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The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis Public Deposited

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  • The purpose of this review is to stimulate new ideas regarding low-dose environmental mixtures and carcinogens and their potential to promote invasion and metastasis. Whereas a number of chapters in this review are devoted to the role of lowdose environmental mixtures and carcinogens in the promotion of invasion and metastasis in specific tumors such as breast and prostate, the overarching theme is the role of low-dose carcinogens in the progression of cancer stem cells. It is becoming clearer that cancer stem cells in a tumor are the ones that assume invasive properties and colonize distant organs. Therefore, low-dose contaminants that trigger epithelial–mesenchymal transition, for example, in these cells are of particular interest in this review. This we hope will lead to the collaboration between scientists who have dedicated their professional life to the study of carcinogens and those whose interests are exclusively in the arena of tissue invasion and metastasis.
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  • Ochieng, J., Nangami, G. N., Ogunkua, O., Miousse, I. R., Koturbash, I., Odero-Marah, V., ... & Eltom, S. E. (2015). The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis. Carcinogenesis, 36(Suppl 1), S128-S159. doi:10.1093/carcin/bgv034
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  • 36
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  • Supp. 1
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  • National Institute of Environmental Health Sciences(R13ES023276); National Institute on Minority Health and HealthDisparities-NIMHD (G12 MD007586 to J.O.), Fondazione Cariplo(2011-0370 to C.M.), Kuwait Institute for the Advancement ofSciences (2011-1302-06 to F.al-M), Grant University Scheme(RUGs) Ministry of Education Malaysia (04-02-12-2099RU to R.A.H),Italian Ministry of University and Research (2009FZZ4XM_002to A.A.), The University of Florence (ex60%2012 to A.A.), USPublic Health Service Grants (R01 CA92306, R01 CA92306-S1,R01 CA113447 to R.R.), Department of Science and Technology,Government of India (SR/FT/LS-063/2008 to N.S.).
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  • description.provenance : Made available in DSpace on 2015-07-15T18:26:09Z (GMT). No. of bitstreams: 1 BissonWilliamHEnvironmentalMolecularToxicologyImpactLowDose.pdf: 2594016 bytes, checksum: e1ebfab9a5c9c30982bc361d086c5b2b (MD5) Previous issue date: 2015-06
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