Fish production is a source of livelihood for millions of Nigerians both as primary and secondary income provider. The study examined the economics of fish harvesting in Yola, Nigeria with the objectives of examining the socioeconomic status of the fishers, determining the gross margin of fish harvesting , examining the variable influencing fish harvesting and identifying the constraints to fish harvesting in the study area. Primary data were collected from 40 randomly selected fishers. The data were subjected to descriptive statistics, gross margin and multiple regression analyses. Majority (67.5%) of the fishers are below the age of 30 with 45% having at least 3 years experience in the job. The result shows that the venture is profitable with the average Gross Margin of N27, 434.38 ($171.46) per month. The result of the regression model revealed that labour input, age of the fishers and the cost of fishing gear are the major determinants of the fish harvesting in the study area. The major constraints to fish harvesting include; high cost of fishing gear, lack of capital and uncertainties associated with the venture. It is recommended that inputs such as fishing gears, trap feeds should be made available and at subsidized prices.