This paper is intended to perform cost-benefit, break-even and sensibility analysis of higher-place pond culture of Penaeus vannamei through a case study of a farmer in Zhanjiang City of Guangdong Province, using cost-benefit data about this farmer’s higher-place pond culture of Penaeus vannamei collected from field survey. Major findings of this study include: (1) The variable costs, as a component of the cost structure, are prime costs that include feed cost, utilities, and manure & shrimp drug expenses, of which the feed cost is the largest contributor; fixed costs make up a smaller share of total costs, of which the fixed labor cost and depreciation of fixed assets are prime costs, and the former is the largest contributor. (2) The higher-placepond culture of Penaeus vannamei is robustly resistant to the risks associated with market price fluctuation and uncertainties and yields high economic benefits. (3) The net margin is most sensitive to price, followed by variable costs and fixed costs. Finally, relevant suggestions on how to help farmers (or aquaculture businesses) increase their economic benefits are proposed based on the above findings.