Other Scholarly Content

 

Fructokinase, Fructans, Intestinal Permeability, and Metabolic Syndrome: An Equine Connection? Public Deposited

Downloadable Content

Download PDF
https://ir.library.oregonstate.edu/concern/defaults/2r36tz35r

This is the author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier and can be found at:  http://www.journals.elsevier.com/journal-of-equine-veterinary-science/.

Descriptions

Attribute NameValues
Creator
Abstract
  • Fructose is a simple sugar present in honey and fruit, but can also exist as a polymer (fructans) in pasture grasses. Mammals are unable to metabolize fructans, but certain gram positive bacteria contain fructanases and can convert fructans to fructose in the gut. Recent studies suggest that fructose generated from bacteria, or directly obtained from the diet, can induce both increased intestinal permeability and features of metabolic syndrome, especially the development of insulin resistance. The development of insulin resistance is driven in part by the metabolism of fructose by fructokinase C in the liver, which results in oxidative stress in the hepatocyte. Similarly, the metabolism of fructose in the small bowel by intestinal fructokinase may lead to increased intestinal permeability and endotoxemia. While speculative, these observations raise the possibility that the mechanism by which fructans induce laminitis could involve intestinal and hepatic fructokinase. Further studies are indicated to determine the role of fructanases, fructose and fructokinase in equine metabolic syndrome and laminitis.
Resource Type
DOI
Date Available
Date Issued
Citation
  • Johnson, R., Rivard, C., Lanaspa, M., Otabachian-Smith, S., Ishimoto, T., Cicerchi, C., . . . Hess, T. (2013). Fructokinase, fructans, intestinal permeability, and metabolic syndrome: An equine connection? Journal of Equine Veterinary Science, 33(2), 120-126. doi: 10.1016/j.jevs.2012.05.004
Series
Keyword
Rights Statement
Funding Statement (additional comments about funding)
  • Supported by NIH grants HL-68607 and startup funds from the Department of Medicine to Dr Richard J Johnson.
Publisher
Peer Reviewed
Language
Replaces
Additional Information
  • description.provenance : Approved for entry into archive by Deanne Bruner(deanne.bruner@oregonstate.edu) on 2013-04-08T17:39:50Z (GMT) No. of bitstreams: 1 CheekePeterAnimalScienceFructokinaseFructansIntestinal.pdf: 315000 bytes, checksum: e4edbb9ff05b768de40c4ffaa2d8c0d6 (MD5)
  • description.provenance : Made available in DSpace on 2013-04-08T17:39:50Z (GMT). No. of bitstreams: 1 CheekePeterAnimalScienceFructokinaseFructansIntestinal.pdf: 315000 bytes, checksum: e4edbb9ff05b768de40c4ffaa2d8c0d6 (MD5) Previous issue date: 2013-02
  • description.provenance : Submitted by Deanne Bruner (deanne.bruner@oregonstate.edu) on 2013-04-08T17:39:03Z No. of bitstreams: 1 CheekePeterAnimalScienceFructokinaseFructansIntestinal.pdf: 315000 bytes, checksum: e4edbb9ff05b768de40c4ffaa2d8c0d6 (MD5)

Relationships

Parents:

This work has no parents.

Items