Infecciones causadas por Clostridium difficile: una visión actualizada Public Deposited

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  • Clostridium difficile associated infections: an updated view
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  • English: Clostridium difficile is an emerging anaerobic, spore forming pathogen, recognized as the etiological agent of ~ 30% of antibiotic associated diarrheas. Clinical symptoms can fluctuate from mild to moderate diarrhea, pseudomembranous colitis and toxic megacolon. The incidence of C. difficile associated infections (CDAI) is ~ 1% of total hospitalized patients. CDAI has a mortality rate of ~1 to 5%, and a relapse rate of ~ 20%. The appearance of severe outbreaks of CDAI could be attributed to changes in the production of the two major virulence factors, the enterotoxins TcdA and TcdB, which produce massive epithelial damage. C. difficile spores play an essential role in transmission, initiation and persistence of CDAI. Recent advances in detection methods, development of novel therapies and prevention methods could allow a reduction on the frequency of CDAI. The objective of this review is to provide an updated view on the mechanisms of pathogenesis, epidemiology, risk factors, detection methods, treatment and prevention of CDAI. Spanish: Clostridium difficile es un patógeno emergente, anaerobio estricto, capaz de formar esporas, y reconocido como el agente etiológico de ~30% de las diarreas asociadas al uso de antimicrobianos. Los síntomas clínicos varían desde una diarrea leve a una colitis pseudomembranosa o megacolon tóxico. La incidencia de las infecciones asociadas a C. difficile (IACD) es de ~1% del total de pacientes hospitalizados y su tasa de mortalidad es de ~1,a 5%, con una elevada tasa de recurrencia de ~20%. Cambios en los principales factores de virulencia como es la producción de dos enterotoxinas, TcdA y TcdB, que provocan daño epitelial, pueden explicar recientes brotes graves de IACD. Las esporas de C. difficile juegan un rol esencial en la transmisión, iniciación y persistencia de las IACD. Novedosos avances en métodos diagnósticos, desarrollo de nuevas terapias y métodos de prevención podrían reducir las tasas de incidencia y su gravedad. El objetivo de esta revisión es entregar una actualización sobre los mecanismos de patogénesis, epidemiología, factores de riesgo, métodos de detección, tratamientos y prevención de las IACD.
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  • HERNANDEZ-ROCHA, Cristian; NAOUR, Sebastián; ALVAREZ-LOBOS, Manuel and PAREDES-SABJA, Daniel. Clostridium difficile associated infections: an updated view. Revista chilena de infectología. [online]. 2012, vol.29, n.4, pp. 434-445. ISSN 0716-1018. doi: 10.4067/S0716-10182012000400011.
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  • description.provenance : Made available in DSpace on 2013-04-19T19:17:06Z (GMT). No. of bitstreams: 1 Paredes-SabjaDanielVeterinaryMedicineInfeccionesCausadasClostridium.pdf: 231731 bytes, checksum: a1b3b0234cea385da3029a3eff94a9d3 (MD5) Previous issue date: 2012-08
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