Identification of gold nanoparticle-resistant mutants of Saccharomyces cerevisiae suggests a role for respiratory metabolism in mediating toxicity Public Deposited

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This is the publisher’s final pdf. The published article is copyrighted by the American Society for Microbiology and can be found at:  http://aem.asm.org/. The accepted manuscript is also provided.

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  • Positively-charged gold nanoparticles (0.8-nm core diameter) reduced yeast survival, but not growth, at a concentration of 10 to 100 μg/ml. Among 17 resistant deletion mutants isolated in a genome-wide screen, highly significant enrichment was observed for respiration-deficient mutants lacking genes encoding proteins associated with the mitochondrion.
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  • Smith, M. R., Boenzli, M. G., Hindagolla, V., Ding, J., Miller, J. M., Hutchison, J. E., . . . Bakalinsky, A. T. (2013). Identification of gold nanoparticle-resistant mutants of saccharomyces cerevisiae suggests a role for respiratory metabolism in mediating toxicity. Applied and Environmental Microbiology, 79(2), 728-733. doi: 10.1128/AEM.01737-12
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  • description.provenance : Submitted by Deanne Bruner (deanne.bruner@oregonstate.edu) on 2013-03-30T00:36:19Z No. of bitstreams: 1 BakalinskyAlanFoodScienceTechnologyIdentificationGoldNanoparticle.pdf: 324539 bytes, checksum: bf915628dda771d8d06a1f011b848ed5 (MD5)
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  • description.provenance : Approved for entry into archive by Deanne Bruner(deanne.bruner@oregonstate.edu) on 2013-03-30T00:37:40Z (GMT) No. of bitstreams: 1 BakalinskyAlanFoodScienceTechnologyIdentificationGoldNanoparticle.pdf: 324539 bytes, checksum: bf915628dda771d8d06a1f011b848ed5 (MD5)

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