Infiltrative Myxoma of the Stifle Joint and Thigh in a Domestic Rabbit (Oryctolagus cuniculus) Public Deposited

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This is the author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier and can be found at:  http://www.journals.elsevier.com/journal-of-comparative-pathology/.

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  • A 5-year-old, male, domestic rabbit had severe swelling of the left rear leg. Radiographs demonstrated a proliferative, infiltrative lesion involving the stifle joint, femur, and soft tissues of the thigh. Osteomyelitis or neoplasia was suspected, and the leg was surgically amputated. Grossly, a multilobular mass comprised cyst-like structures containing yellow mucinous material. Histologically, the mass formed coalescing lobules of stellate to rounded cells embedded in varying amounts of myxoid to collagenous matrix; some rimmed by narrow walls of metaplastic bone and/or cartilage; some infiltrated with plasma cells, lymphocytes, heterophils and histiocytes. On immunohistochemistry, neoplastic cells stained for vimentin but were negative for cytokeratin, sarcomeric actin, Mac387 and BLA.36. Cytokeratin was not detected in normal synovial cells. Radiographic, gross and histological findings are consistent with synovial myxoma seen in dogs and humans; however, because of extensive involvement of the limb in absence of confirmed metastatic disease, the term infiltrative synovial myxoma was applied.
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  • Löhr, C. V., Hedge, Z. N., & Pool, R. R. (2012). Infiltrative myxoma of the stifle joint and thigh in a domestic rabbit (oryctolagus cuniculus). Journal of Comparative Pathology, 147(2-3), 218-222. doi: 10.1016/j.jcpa.2012.01.020
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  • description.provenance : Submitted by Deanne Bruner (deanne.bruner@oregonstate.edu) on 2013-03-22T21:12:49Z No. of bitstreams: 2 LoehrChristianeVeterinary MedicineInfiltrativeMyxomaStifle(Figures1-4).pdf: 231870 bytes, checksum: f21bb7995a405c262e320c130c5262b1 (MD5) LoehrChristianeVeterinary MedicineInfiltrativeMyxomaStifle.pdf: 151541 bytes, checksum: 46406bbf16cea0db2e48fada80096f7b (MD5)
  • description.provenance : Approved for entry into archive by Deanne Bruner(deanne.bruner@oregonstate.edu) on 2013-03-22T21:22:54Z (GMT) No. of bitstreams: 2 LoehrChristianeVeterinary MedicineInfiltrativeMyxomaStifle(Figures1-4).pdf: 231870 bytes, checksum: f21bb7995a405c262e320c130c5262b1 (MD5) LoehrChristianeVeterinary MedicineInfiltrativeMyxomaStifle.pdf: 151541 bytes, checksum: 46406bbf16cea0db2e48fada80096f7b (MD5)
  • description.provenance : Made available in DSpace on 2013-03-22T21:22:54Z (GMT). No. of bitstreams: 2 LoehrChristianeVeterinary MedicineInfiltrativeMyxomaStifle(Figures1-4).pdf: 231870 bytes, checksum: f21bb7995a405c262e320c130c5262b1 (MD5) LoehrChristianeVeterinary MedicineInfiltrativeMyxomaStifle.pdf: 151541 bytes, checksum: 46406bbf16cea0db2e48fada80096f7b (MD5) Previous issue date: 2012-08

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