Tacrolimus Pharmacokinetics in Hispanic Children After Kidney Transplantation Public Deposited

http://ir.library.oregonstate.edu/concern/defaults/9019s339f

This is the author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier and can be found at:  http://www.journals.elsevier.com/transplantation-proceedings/.

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  • Ethnic differences in drug pharmacokinetics are well recognized including that for tacrolimus (TAC) in adult subjects. However, similar knowledge among pediatric populations is missing. Our limited retrospective study compares steady-state pharmacokinetics of TAC in Hispanic versus non-Hispanic children. Serial blood samples were collected and whole blood concentrations of TAC were measured using radioimmunoassay. Compared with non-Hispanic children, Hispanic children had lower measures of drug exposure (maximum drug concentration [C(subscript max)] and area under the drug concentration-time curve [AUC(subscript 0-∞)]), higher volume of distribution, and faster clearance. Interestingly, only in Hispanic children, significant correlations were found between body weight and clearance, age and volume of distribution, and Schwartz estimated glomerular filtration rate and half-life. In conclusion, our study suggests that ethnic differences exist between Hispanic and non-Hispanic children in TAC PK, and based on our preliminary findings, either a higher or more frequent TAC dosing may be required for effective immunosuppression therapy in Hispanic children.
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  • Cherala, G., Munar, M., Naher, A., & Al-Uzri, A. (2011). Tacrolimus pharmacokinetics in hispanic children after kidney transplantation. TRANSPLANTATION PROCEEDINGS, 43(10), 3708-3712. doi: 10.1016/j.transproceed.2011.09.016
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  • description.provenance : Submitted by Deanne Bruner (deanne.bruner@oregonstate.edu) on 2012-10-10T18:06:56Z No. of bitstreams: 1 CheralaGaneshPharmacyTacrolimusPharmacokineticsHispanic.pdf: 461358 bytes, checksum: cf2eb92ef0324d571e00e4c44ee7c989 (MD5)
  • description.provenance : Submitted by Deanne Bruner (deanne.bruner@oregonstate.edu) on 2012-10-10T17:14:00Z No. of bitstreams: 1 CheralaGaneshPharmacyTacrolimusPharmacokineticsHispanic.pdf: 461358 bytes, checksum: cf2eb92ef0324d571e00e4c44ee7c989 (MD5)
  • description.provenance : Made available in DSpace on 2012-10-10T18:07:48Z (GMT). No. of bitstreams: 1 CheralaGaneshPharmacyTacrolimusPharmacokineticsHispanic.pdf: 461358 bytes, checksum: cf2eb92ef0324d571e00e4c44ee7c989 (MD5) Previous issue date: 2011-12
  • description.provenance : Rejected by Deanne Bruner(deanne.bruner@oregonstate.edu), reason: SubSCRIPT not subfield! on 2012-10-10T18:00:25Z (GMT)
  • description.provenance : Approved for entry into archive by Deanne Bruner(deanne.bruner@oregonstate.edu) on 2012-10-10T18:07:48Z (GMT) No. of bitstreams: 1 CheralaGaneshPharmacyTacrolimusPharmacokineticsHispanic.pdf: 461358 bytes, checksum: cf2eb92ef0324d571e00e4c44ee7c989 (MD5)

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