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Preliminary safety study for an equine (Equus caballus) vaccine against sperm acrosome associated 3 protein Public Deposited

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https://ir.library.oregonstate.edu/concern/defaults/bc386s27q

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  • In the United States, the wild horse population exceeds the recommended carrying capacity by about 60,000 horses. • Current contraceptive methods include: surgical (removal of ovaries), hormonal (progesterone, GnRH), and immunologic (porcine zona pellucida, GnRH). • SPACA3 is a sperm surface membrane protein involved in sperm-egg plasma membrane adhesion and fusion during fertilization, and has been identified in men, cattle, sheep, and deer. • SPACA3 has also been identified in the granulosa cells and ooplasm in dogs and cats.
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