Dietary lignan and proanthocyanidin consumption and colorectal adenoma recurrence in the Polyp Prevention Trial Public Deposited

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  • Lignans and proanthocyanidins are plant polyphenols that have shown protective properties against colorectal neoplasms in some human studies. Using logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) to prospectively evaluate the association between lignan and proanthocyanidin intake, estimated from databases linked to a food frequency questionnaire, and adenoma recurrence in 1,859 participants of the Polyp Prevention Trial. Overall, individual or total lignans or proanthocyanidins were not associated with colorectal adenoma recurrence. However, in sex-specific analyses, total lignan intake was positively associated with any adenoma recurrence in women (highest vs. lowest lignan intake quartile OR = 2.07, 95% CI: 1.223.52, p trend = 0.004) but not in men (p interaction = 0.04). To conclude, dietary lignan and proanthocyanidin consumption were not generally related to colorectal adenoma recurrence; however, high lignan intake may increase the risk of adenoma recurrence in women.
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  • Bobe, G., Murphy, G., Albert, P. S., Sansbury, L. B., Lanza, E., Schatzkin, A., & Cross, A. J. (2012). Dietary lignan and proanthocyanidin consumption and colorectal adenoma recurrence in the polyp prevention trial. International Journal of Cancer. Journal International Du Cancer, 130(7), 1649-1659. doi: 10.1002/ijc.26184
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  • description.provenance : Submitted by Deborah Campbell (deborah.campbell@oregonstate.edu) on 2012-10-31T18:16:15Z No. of bitstreams: 1 BobeGerdAnimalSciencesDietaryLignanProanthocyanidin.pdf: 837347 bytes, checksum: a022dcd3f81fe28e363ee04b55b1aa0f (MD5)
  • description.provenance : Made available in DSpace on 2012-10-31T18:31:28Z (GMT). No. of bitstreams: 1 BobeGerdAnimalSciencesDietaryLignanProanthocyanidin.pdf: 837347 bytes, checksum: a022dcd3f81fe28e363ee04b55b1aa0f (MD5) Previous issue date: 2012-04-01
  • description.provenance : Approved for entry into archive by Deborah Campbell(deborah.campbell@oregonstate.edu) on 2012-10-31T18:31:28Z (GMT) No. of bitstreams: 1 BobeGerdAnimalSciencesDietaryLignanProanthocyanidin.pdf: 837347 bytes, checksum: a022dcd3f81fe28e363ee04b55b1aa0f (MD5)

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