Bovine acute-phase response after different doses of corticotropin-releasing hormone challenge¹,²,³ Public Deposited

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  • The objective was to compare the acute-phase response of steers receiving different doses of bovine corticotropin-releasing hormone (CRH). Fourteen weaned Angus steers (BW = 191 ± 2.1 kg, age = 167 ± 4.7 d) fitted with an indwelling jugular catheter and a rectal temperature (RT) monitoring device were assigned to receive 1 of 3 treatments (intravenous infusion): 1) 0.1 μg of CRH/kg of BW (CRH1; n = 5), 2) 0.5 μg of CRH/kg of BW (CRH5; n = 5), and 3) 10 mL of saline (0.9%; n = 4). Blood samples were collected via catheters, relative to treatment infusion (0 h), hourly from –2 to 0 h and 4 to 8 h and every 30 min from 0 to 4 h. Rectal temperatures were recorded every 30 min from −2 to 8 h. Blood samples were also collected via jugular venipuncture and rectal temperatures assessed using a digital thermometer every 6 h from 12 to 72 h and every 24 h from 96 to 168 h. All plasma samples collected during the study were analyzed for concentrations of haptoglobin. All plasma samples collected from –2 to 8 h were analyzed for cortisol concentrations. Serum samples collected hourly from −2 to 8 h were analyzed for concentrations of NEFA, IL-6, tumor necrosis factor (TNF)-α, and interferon-γ. Cortisol peaked at 0.5 h for CRH1 steers but returned to baseline concentrations at 1 h relative to infusion (time effect; P < 0.01). In CRH5 steers, cortisol peaked at 0.5 h and returned to baseline concentrations 3.5 h relative to infusion (time effect; P < 0.01). Cortisol concentrations did not change after treatment infusion for saline steers (time effect; P = 0.42). In CRH1 steers, NEFA concentrations peaked 5 h after treatment infusion (time effect; P = 0.01). Conversely, serum NEFA concentrations did not change for CRH5 and saline steers after treatment infusion (time effect; P > 0.37). Mean serum TNF-α concentrations in CRH1 steers after treatment infusion were greater compared with saline (P = 0.02), tended to be greater (P = 0.08) compared with CRH5, and were similar (P = 0.40) between CRH5 and saline steers. Mean RT in CRH1 steers after treatment infusion were greater (P < 0.04) compared with saline and CRH5 and similar (P = 0.50) between CRH5 and saline steers. Haptoglobin increased and peaked 72 h after treatment infusion for CRH1 steers (time effect; P = 0.01) but did not change for CRH5 and saline steers (time effect; P > 0.45). In conclusion, the bovine acute-phase response stimulated by CRH infusion is dependent on the CRH dose and the subsequent response in circulating cortisol.
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  • Cooke, R. F., Carroll, J. A., Dailey, J., Cappellozza, B. I., & Bohnert, D. W. (2012). Bovine acute-phase response after different doses of corticotropin-releasing hormone challenge. Journal of Animal Science, 90(7), 2337-2344. doi: 10.2527/jas2011-4608
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  • description.provenance : Approved for entry into archive by Deanne Bruner(deanne.bruner@oregonstate.edu) on 2012-08-21T20:19:08Z (GMT) No. of bitstreams: 1 CookeReinaldoAnimalSciencesBovineAcutePhase.pdf: 829853 bytes, checksum: 38adfc20f1b2b839a69c1675c2012af7 (MD5)
  • description.provenance : Submitted by Deanne Bruner (deanne.bruner@oregonstate.edu) on 2012-08-21T20:18:15Z No. of bitstreams: 1 CookeReinaldoAnimalSciencesBovineAcutePhase.pdf: 829853 bytes, checksum: 38adfc20f1b2b839a69c1675c2012af7 (MD5)
  • description.provenance : Made available in DSpace on 2012-08-21T20:19:08Z (GMT). No. of bitstreams: 1 CookeReinaldoAnimalSciencesBovineAcutePhase.pdf: 829853 bytes, checksum: 38adfc20f1b2b839a69c1675c2012af7 (MD5) Previous issue date: 2012-07

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