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Identification of Novel Biomarkers in urine from Canine Transitional Cell Carcinoma Patients

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  • • Bladder Cancer in the United States has progressively been one of the more common cancers and is estimated to have 74,000 new cases as well as 16,000 deaths in 2015.1 • This type of cancer also has one of the highest rates of recurrence with an average of 60% within 5 years and 90% after 15 years.2 • Canine TCC was found to resemble the same malignancy in humans when comparing histopathological characteristics, molecular features, and biological behavior.3 • Previous research has shown that the lipid profiles between canine TCC bladder tissues and normal bladder tissues differ. This discovery was then applied to human bladder cancer tissues and similarities of the lipid profiles between human bladder cancer and canine TCC were identified.4 • We hypothesized that the lipidomic profiles of the urine extracted from canines with TCC, UTI, and healthy bladders will exhibit different signatures. • The following study had two objectives. The first, to identify an ideal method for lipid extraction from urine samples of dogs with TCC, Urinary Tract Infections (UTI), and healthy bladders. The second, to determine the differences in the lipid profiles extracted from the urine of the three cohorts.
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