Multifunctional Nanomedicine Platform for Concurrent Delivery of Chemotherapeutic Drugs and Mild Hyperthermia to Ovarian Cancer Cells Public Deposited

http://ir.library.oregonstate.edu/concern/defaults/gf06g3652

This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier and can be found at:  http://www.journals.elsevier.com/international-journal-of-pharmaceutics/.

Supplementary Data content is available on the Elsevier article site.

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • A multifunctional tumor-targeting delivery system was developed and evaluated for an efficient treatment of drug-resistant ovarian cancer by combinatorial therapeutic modality based on chemotherapy and mild hyperthermia. The engineered iron oxide nanoparticle (IONPs)-based nanocarrier served as an efficient delivery vehicle for doxorubicin and provided the ability to heat cancer cells remotely upon exposure to an alternating magnetic field (AMF). The nanocarrier was additionally modified with polyethylene glycol and LHRH peptide to improve its biocompatibility and ability to target tumor cells. The synthesized delivery system has an average size of 97.1 nm and a zeta potential close to zero, both parameters favorable for increased stability in biological media and decreased elimination by the immune system. The nanocarrier demonstrated faster drug release in acidic conditions that mimic the tumor environment. It was also observed that the LHRH targeted delivery system could effectively enter drug resistant ovarian cancer cells, and the fate of doxorubicin was tracked with fluorescence microscope. Mild hyperthermia (40 °C) generated by IONPs under exposure to AMF synergistically increased the cytotoxicity of doxorubicin delivered by the developed nanocarrier to cancer cells. Thus, the developed IONPs-based delivery system has high potential in the effective treatment of ovarian cancer by combinatorial approach.
Resource Type
DOI
Date Available
Date Issued
Citation
  • Taratula, O., Dani, R.K., Schumann, C., Xu, H., Wang, A., Song, H., Dhagat, P., Taratula, O. (2013). Multifunctional Nanomedicine Platform for Concurrent Delivery of Chemotherapeutic Drugs and Mild Hyperthermia to Ovarian Cancer Cells. International Journal of Pharmaceutics, 458(1), 169-180. doi.10.1016/j.ijpharm.2013.09.032
Academic Affiliation
Series
Keyword
Rights Statement
Funding Statement (additional comments about funding)
Publisher
Peer Reviewed
Language
Replaces
Additional Information
  • description.provenance : Made available in DSpace on 2013-10-02T19:47:19Z (GMT). No. of bitstreams: 1 TaratulaOlehPharmacyMultifunctionalNanomedicinePlatform.pdf: 1306948 bytes, checksum: a73f53d393608ab245f24f80a26a0988 (MD5) Previous issue date: 2013
  • description.provenance : Approved for entry into archive by Deanne Bruner(deanne.bruner@oregonstate.edu) on 2013-10-02T19:47:19Z (GMT) No. of bitstreams: 1 TaratulaOlehPharmacyMultifunctionalNanomedicinePlatform.pdf: 1306948 bytes, checksum: a73f53d393608ab245f24f80a26a0988 (MD5)
  • description.provenance : Submitted by Deanne Bruner (deanne.bruner@oregonstate.edu) on 2013-10-02T19:46:23Z No. of bitstreams: 1 TaratulaOlehPharmacyMultifunctionalNanomedicinePlatform.pdf: 1306948 bytes, checksum: a73f53d393608ab245f24f80a26a0988 (MD5)

Relationships

Parents:

This work has no parents.

Last modified

Downloadable Content

Download PDF

Items