Transplacental Carcinogenesis with Dibenzo[def,p]chrysene (DBC): Timing of Maternal Exposures Determines Target Tissue Response in Offspring Public Deposited

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This is the author's peer reviewed final manuscript as accepted by the publisher. The published article is copyrighted by Elsevier and can be found here:  http://www.elsevier.com/wps/find/journaldescription.cws_home/506050/description#description

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  • Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15 mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received 4 smaller doses of DBC (3.75 mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established carcinogenic responses in the thymus, lung, and liver. However, there was a marked increase in ovarian tumors (females) and hyperplastic testes (males). [¹⁴C]-DBC (GD 17) dosing revealed transplacental distribution to fetal tissues at 10-fold lower concentrations than in paired maternal tissue and residual [¹⁴C] 3 weeks post dose. This study highlights the importance of developmental stage in susceptibility to environmental carcinogens.
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  • L. Shorey, D.J. Castro, W. Baird, B. Siddens, C. Löhr, M. Matzke, K.M. Waters, R.A. Corley, D.E. Williams, Transplacental Carcinogenesis with Dibenzo[def,p]chrysene (DBC): Timing of Maternal Exposures Determines Target Tissue Response in Offspring, Cancer Letters (2011), doi: 10.1016/j.canlet. 2011.11.010
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  • description.provenance : Approved for entry into archive by Sue Kunda(sue.kunda@oregonstate.edu) on 2011-11-17T23:27:25Z (GMT) No. of bitstreams: 1 WilliamsDavid.EnvironMolecularToxicology.TransplacentalCarcinogenesisDibenzo.pdf: 5525210 bytes, checksum: dd3666753864fd946b83ed68046efa64 (MD5)
  • description.provenance : Made available in DSpace on 2011-11-17T23:27:25Z (GMT). No. of bitstreams: 1 WilliamsDavid.EnvironMolecularToxicology.TransplacentalCarcinogenesisDibenzo.pdf: 5525210 bytes, checksum: dd3666753864fd946b83ed68046efa64 (MD5) Previous issue date: 2011
  • description.provenance : Submitted by Sue Kunda (sue.kunda@oregonstate.edu) on 2011-11-17T23:27:06Z No. of bitstreams: 1 WilliamsDavid.EnvironMolecularToxicology.TransplacentalCarcinogenesisDibenzo.pdf: 5525210 bytes, checksum: dd3666753864fd946b83ed68046efa64 (MD5)

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