Hypertension and low HDL cholesterol were associated with reduced kidney function across the age spectrum: a collaborative study Public Deposited

http://ir.library.oregonstate.edu/concern/defaults/k643b202h

To the best of our knowledge, one or more authors of this paper were federal employees when contributing to this work. This is the publisher’s final pdf. The published article is copyrighted by Elsevier and can be found at:  http://www.elsevier.com/.

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • Purpose: To determine if the associations among established risk factors and reduced kidney function vary by age. Methods: We pooled cross-sectional data from 14,788 nondiabetics aged 40 to 100 years in 4 studies: Cardiovascular Health Study, Health, Aging, and Body Composition Study, Multi-Ethnic Study of Atherosclerosis, and Prevention of Renal and Vascular End-Stage Disease cohort. Results: Hypertension and low high-density lipoprotein (HDL) cholesterol were associated with reduced cystatin C-based estimated glomerular filtration rate (eGFR) across the age spectrum. In adjusted analyses, hypertension was associated with a 23 (95% confidence interval [CI], 0.1, 4.4), 5.1 (95% Cl, 4.1, 6.1), and 6.9 (95% CI, 3.0, 10.4) mL/min/1.73 m(2) lower eGFR in participants 40 to 59, 60 to 79, and at least 80 years, respectively (P for interaction < .001). The association of low HDL cholesterol with reduced kidney function was also greater in the older age groups: 4.9 (95% CI, 3.5, 6.3), 7.1 (95% CI, 6.0, 83), 8.9 (95% CI, 5.4,11.9) mL/min/1.73 m(2) (P for interaction < .001). Smoking and obesity were associated with reduced kidney function in participants under 80 years. All estimates of the potential population impact of the risk factors were modest. Conclusions: Hypertension, obesity, smoking, and low HDL cholesterol are modestly associated with reduced kidney function in nondiabetics. The associations of hypertension and HDL cholesterol with reduced kidney function seem to be stronger in older adults. (C) 2013 Elsevier Inc. All rights reserved.
Resource Type
DOI
Date Available
Date Issued
Citation
  • Odden, M. C., Sarnak, M. J., Siscovick, D., Shlipak, M. G., Tager, I. B., Gansevoort, R. T., . . . Harris, T. B. (2013). Hypertension and low HDL cholesterol were associated with reduced kidney function across the age spectrum: A collaborative study. Annals of Epidemiology, 23(3), 106-111. doi: 10.1016/j.annepidem.2012.12.004
Academic Affiliation
Series
Keyword
Rights Statement
Funding Statement (additional comments about funding)
Publisher
Peer Reviewed
Language
Replaces
Additional Information
  • description.provenance : Approved for entry into archive by Deborah Campbell(deborah.campbell@oregonstate.edu) on 2013-04-01T16:53:30Z (GMT) No. of bitstreams: 1 OddenMichelleCPublicHealthHumanSciencesHypertensionLowHDL.pdf: 188912 bytes, checksum: 6a5f20edb33acc74146f67577e14691e (MD5)
  • description.provenance : Submitted by Deborah Campbell (deborah.campbell@oregonstate.edu) on 2013-04-01T16:44:22Z No. of bitstreams: 1 OddenMichelleCPublicHealthHumanSciencesHypertensionLowHDL.pdf: 188912 bytes, checksum: 6a5f20edb33acc74146f67577e14691e (MD5)
  • description.provenance : Made available in DSpace on 2013-04-01T16:53:30Z (GMT). No. of bitstreams: 1 OddenMichelleCPublicHealthHumanSciencesHypertensionLowHDL.pdf: 188912 bytes, checksum: 6a5f20edb33acc74146f67577e14691e (MD5) Previous issue date: 2013-03

Relationships

Parents:

This work has no parents.

Last modified

Downloadable Content

Download PDF

Items