Potent DNA damage by polyhalogenated quinones and H2O2 via a metal-independent and Intercalation-enhanced oxidation mechanism Public Deposited

http://ir.library.oregonstate.edu/concern/defaults/kw52j898z

This is the publisher’s final pdf. The published article is copyrighted by Nature Publishing Group and can be found at:  http://www.nature.com/.

Descriptions

Attribute NameValues
Alternative Title
  • Potent DNA damage by polyhalogenated quinones and H[subscript 2]O[subscript 2] via a metal-independent and Intercalation-enhanced oxidation mechanism
Creator
Abstract or Summary
  • Polyhalogenated quinones are a class of carcinogenic intermediates. We found recently that the highly reactive and biologically/environmentally important center [dot]OH can be produced by polyhalogenated quinones and H₂O₂ independent of transition metal ions. However, it is not clear whether this unusual metal-independent center dot OH producing system can induce potent oxidative DNA damage. Here we show that TCBQ and H₂O₂ can induce oxidative damage to both dG and dsDNA; but surprisingly, it was more efficient to induce oxidative damage in dsDNA than in dG. We found that this is probably due to its strong intercalating ability to dsDNA through competitive intercalation assays. The intercalation of TCBQ in dsDNA may lead to center dot OH generation more adjacent to DNA. This is the first report that polyhalogenated quinoid carcinogens and H₂O₂ can induce potent DNA damage via a metal- independent and intercalation-enhanced oxidation mechanism, which may partly explain their potential genotoxicity, mutagenesis, and carcinogenicity
Resource Type
DOI
Date Available
Date Issued
Citation
  • Yin, R., Zhang, D., Song, Y., Zhu, B., & Wang, H. (2013). Potent DNA damage by polyhalogenated quinones and H(2)O(2) via a metal-independent and intercalation-enhanced oxidation mechanism. Scientific Reports, 3, 1269. doi: 10.1038/srep01269
Non-Academic Affiliation
Series
Keyword
Rights Statement
Funding Statement (additional comments about funding)
Publisher
Peer Reviewed
Language
Replaces
Additional Information
  • description.provenance : Made available in DSpace on 2013-03-11T17:50:42Z (GMT). No. of bitstreams: 3 license_rdf: 22765 bytes, checksum: 56265f5776a16a05899187d30899c530 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) ZhuBenZhanLinusPaulingInstitutePotentDNADamage.pdf: 650667 bytes, checksum: 927c762f1faa176f6ea528ac59dc62f4 (MD5) Previous issue date: 2013-02-14
  • description.provenance : Approved for entry into archive by Deborah Campbell(deborah.campbell@oregonstate.edu) on 2013-03-11T17:50:42Z (GMT) No. of bitstreams: 3 license_rdf: 22765 bytes, checksum: 56265f5776a16a05899187d30899c530 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) ZhuBenZhanLinusPaulingInstitutePotentDNADamage.pdf: 650667 bytes, checksum: 927c762f1faa176f6ea528ac59dc62f4 (MD5)
  • description.provenance : Submitted by Deborah Campbell (deborah.campbell@oregonstate.edu) on 2013-03-11T16:31:16Z No. of bitstreams: 3 license_rdf: 22765 bytes, checksum: 56265f5776a16a05899187d30899c530 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) ZhuBenZhanLinusPaulingInstitutePotentDNADamage.pdf: 650667 bytes, checksum: 927c762f1faa176f6ea528ac59dc62f4 (MD5)

Relationships

In Administrative Set:
Last modified: 07/14/2017

Downloadable Content

Download PDF
Citations:

EndNote | Zotero | Mendeley

Items