Other Scholarly Content

 

Absolute humidity and the seasonal onset of influenza in the continental United States Public Deposited

Downloadable Content

Download PDF
https://ir.library.oregonstate.edu/concern/defaults/mc87pr95q

Descriptions

Attribute NameValues
Creator
Abstract
  • Much of the observed wintertime increase of mortality in temperate regions is attributed to seasonal influenza. A recent reanalysis of laboratory experiments indicates that absolute humidity strongly modulates the airborne survival and transmission of the influenza virus. Here, we extend these findings to the human population level, showing that the onset of increased wintertime influenza-related mortality in the United States is associated with anomalously low absolute humidity levels during the prior weeks. We then use an epidemiological model, in which observed absolute humidity conditions temper influenza transmission rates, to successfully simulate the seasonal cycle of observed influenza-related mortality. The model results indicate that direct modulation of influenza transmissibility by absolute humidity alone is sufficient to produce this observed seasonality. These findings provide epidemiological support for the hypothesis that absolute humidity drives seasonal variations of influenza transmission in temperate regions.
Resource Type
DOI
Date Available
Date Issued
Citation
  • Shaman, J., Pitzer, V. E., Viboud, C., Grenfell, B. T., & Lipsitch, M. (2010). Absolute humidity and the seasonal onset of influenza in the continental United States. PLoS Biology, 8(2). doi:10.1371/journal.pbio.1000316
Series
Rights Statement
Funding Statement (additional comments about funding)
  • US National Institutes of Health (NIH) Models of Infectious Disease Agent Study through cooperative agreements 5UO1GM076497 (ML) and 1U54GM088588 (ML and JS). VEP and BG were supported by NIH grant R01GM083983-01, the Bill and Melinda Gates Foundation, the RAPIDD program of the Science and Technology Directorate, US Department of Homeland Security and the Fogarty International Center, NIH.
Publisher
Language
Replaces
Additional Information
  • description.provenance : Approved for entry into archive by Digital Production(digitalproduc@gmail.com) on 2010-10-04T16:59:22Z (GMT) No. of bitstreams: 1 Shaman_et_al_Plos_Biology_2010.pdf: 862255 bytes, checksum: 5a5e2fdcce396a74b6391232316210f1 (MD5)
  • description.provenance : Made available in DSpace on 2010-10-04T16:59:22Z (GMT). No. of bitstreams: 1 Shaman_et_al_Plos_Biology_2010.pdf: 862255 bytes, checksum: 5a5e2fdcce396a74b6391232316210f1 (MD5) Previous issue date: 2010-02-23
  • description.provenance : Submitted by Eric Vanderwall (ewscanner@gmail.com) on 2010-09-23T21:28:04Z No. of bitstreams: 1 Shaman_et_al_Plos_Biology_2010.pdf: 862255 bytes, checksum: 5a5e2fdcce396a74b6391232316210f1 (MD5)

Relationships

Parents:

This work has no parents.

Items