Inhibiting the Receptor Tyrosine Kinase-like Orphan Receptor 2 (ROR2) enzymewith small molecules for the treatment of cancer

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Citeable URL: https://ir.library.oregonstate.edu/concern/defaults/ns064b897

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Attribute Name	Values
Creator	Rodgers, Brett Nishita, Michiru Bisson, William H.
Abstract	Based on recent findings, our hypothesis is that the inhibition of the Receptor tyrosine kinase-like orphan receptor 2 (ROR2) enzyme can lead to tumor suppression. ROR2 are trans-membrane proteins that are part of the receptor tyrosine kinase (RTK) family. ROR2 is generally not expressed in most normal adult tissues and represents a new target in the WNT signaling pathway. In order to test our hypothesis, we have developed a model using transiently transfected HEK-293T cells to screen for inhibition of ROR2-mediated downstream signaling. The inhibition of ROR2 activation, through canonical WNT pathway, will be studied by monitoring the level of activated-ROR2-induced phosphorylation of G-protein coupledreceptor Kinase 2 (GRK2) compared to untreated cells. The research proposed is significant because it will lead to novel lead compounds for multiple tumor types.
Resource Type	Poster
Date Available	2015-12-01T09:00:07+00:00
Date Issued	2015-01-09
Degree Level	Bachelor's
Degree Name	Bachelor of Science (B.S.)
Advisor	Bisson, William
Academic Affiliation	Environmental and Molecular Toxicology
Non-Academic Affiliation	Oregon State University. Undergraduate Research, Scholarship, and the Arts (URSA)
Rights Statement	In Copyright
Publisher	Oregon State University
Peer Reviewed	No
Language	English [eng]
Replaces	http://hdl.handle.net/1957/55915

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