Shadow Enhancers as a Source of Evolutionary Novelty Public Deposited

http://ir.library.oregonstate.edu/concern/defaults/r781wg84m

This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Association for the Advancement of Science and can be found at:  http://www.sciencemag.org/.

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • The dorsal-ventral patterning of the Drosophila embryo is controlled by Dorsal, a sequence-specific transcription factor that is related to mammalian NF-κB. Previous ChIP-chip assays predicted that as many as a third or even half of all Dorsal target genes contain multiple enhancers for the same or similar expression pattern. Here we show that some of these secondary enhancers, or “shadow enhancers”, produce gene expression patterns that overlap those produced by the primary enhancers in transgenic embryos. We suggest that shadow enhancers help ensure the precision of embryonic patterning and discuss their significance in the evolution of genetic novelty.
Resource Type
DOI
Date Available
Date Issued
Citation
  • Hong, J. W., Hendrix, D. A., & Levine, M. S. (2008). Shadow enhancers as a source of evolutionary novelty. Science, 321(5894), 1314. doi:10.1126/science.1160631
Academic Affiliation
Series
Rights Statement
Funding Statement (additional comments about funding)
Publisher
Peer Reviewed
Language
Replaces
Additional Information
  • description.provenance : Made available in DSpace on 2014-06-30T21:06:12Z (GMT). No. of bitstreams: 1 HendrixDavidBiochemistryBiophysicsShadowEnhancers.pdf: 30961 bytes, checksum: 2b9ac59e943a252753d3cd152c0946d9 (MD5) Previous issue date: 2008-09-05
  • description.provenance : Approved for entry into archive by Erin Clark(erin.clark@oregonstate.edu) on 2014-06-30T21:06:12Z (GMT) No. of bitstreams: 1 HendrixDavidBiochemistryBiophysicsShadowEnhancers.pdf: 30961 bytes, checksum: 2b9ac59e943a252753d3cd152c0946d9 (MD5)
  • description.provenance : Submitted by Erin Clark (erin.clark@oregonstate.edu) on 2014-06-30T21:05:46Z No. of bitstreams: 1 HendrixDavidBiochemistryBiophysicsShadowEnhancers.pdf: 30961 bytes, checksum: 2b9ac59e943a252753d3cd152c0946d9 (MD5)

Relationships

Parents:

This work has no parents.

Last modified

Downloadable Content

Download PDF

Items