Shadow Enhancers as a Source of Evolutionary Novelty

Citeable URL: https://ir.library.oregonstate.edu/concern/articles/r781wg84m

Descriptions

Attribute Name	Values
Creator	Hong, Joung-Woo Hendrix, David A. Levine, Michael S.
Abstract	The dorsal-ventral patterning of the Drosophila embryo is controlled by Dorsal, a sequence-specific transcription factor that is related to mammalian NF-κB. Previous ChIP-chip assays predicted that as many as a third or even half of all Dorsal target genes contain multiple enhancers for the same or similar expression pattern. Here we show that some of these secondary enhancers, or “shadow enhancers”, produce gene expression patterns that overlap those produced by the primary enhancers in transgenic embryos. We suggest that shadow enhancers help ensure the precision of embryonic patterning and discuss their significance in the evolution of genetic novelty.
Resource Type	Article
DOI	https://doi.org/10.1126/science.1160631
Date Available	2014-06-30T21:06:12+00:00
Date Issued	2008-09-05
Citation	Hong, J. W., Hendrix, D. A., & Levine, M. S. (2008). Shadow enhancers as a source of evolutionary novelty. Science, 321(5894), 1314. doi:10.1126/science.1160631
Journal Title	Science
Journal Volume	321
Journal Issue/Number	5894
Academic Affiliation	Biochemistry and Biophysics
Dichiarazione dei diritti	In Copyright
Funding Statement (additional comments about funding)	This study was funded by the NIH (GM46638) and Moore Foundation.
Publisher	American Association for the Advancement of Science
Peer Reviewed	Yes
Language	English [eng]
Replaces	http://hdl.handle.net/1957/49890