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Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats

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https://ir.library.oregonstate.edu/concern/articles/rf55z851t

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  • Obesity contributes to increased risk for several chronic diseases including cardiovascular disease and type 2 diabetes. Xanthohumol, a prenylated flavonoid from hops (Humulus lupulus), was tested for efficacy on biomarkers of metabolic syndrome in 4 week old Zucker fa/fa rats, a rodent model of obesity. Rats received daily oral doses of xanthohumol at 0, 1.86, 5.64, and 16.9 mg/kg BW for 6 weeks. All rats were maintained on a high fat (60% kcal) AIN-93G diet for 3 weeks to induce severe obesity followed by a normal AIN-93G (15% kcal fat) diet for the last 3 weeks of the study. Weekly food intake and body weight were recorded. Plasma cholesterol, glucose, insulin, triglyceride, and monocyte chemoattractant protein -1 (MCP-1) levels were assessed using commercial assay kits. Plasma and liver tissue levels of XN and its metabolites were determined by liquid-chromatography tandem mass spectrometry. Plasma and liver tissue levels of xanthohumol were similar between low and medium dose groups and significantly (p<0.05) elevated in the highest dose group. There was a dose-dependent effect on body weight and plasma glucose levels. The highest dose group (n=6) had significantly lower plasma glucose levels compared to the control group (n=6) in male but not female rats. There was also a significant decrease in body weight for male rats in the highest dose group (16.9 mg / kg BW) compared to rats that received no xanthohumol, which was also not seen for female rats. Plasma cholesterol, insulin, triglycerides, and MCP-1 as well as food intake were not affected by treatment. The findings suggest that xanthohumol has beneficial effects on markers of metabolic syndrome.
  • Keywords: Humulus lupulus, Hops, Obesity, Type 2 diabetes, Xanthohumol, Rats, Metabolic syndrome
  • Keywords: Humulus lupulus, Hops, Obesity, Type 2 diabetes, Xanthohumol, Rats, Metabolic syndrome
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  • Legette, L. L., Luna, A. Y. M., Reed, R. L., Miranda, C. L., Bobe, G., Proteau, R. R., & Stevens, J. F. (2013). Xanthohumol lowers body weight and fasting plasma glucose in obese male zucker fa/fa rats. Phytochemistry, 91, 236-241. doi:10.1016/j.phytochem.2012.04.018
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  • 91
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  • This study was supported by the National Institutes of Health (R21AT005294, S10 RR022589 and P30 ES000210).
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