Evolution of a Higher Intracellular Oxidizing Environment in Caenorhabditis elegans under Relaxed Selection

Joyner-Matos, Joanna; Hicks, Kiley A.; Cousins, Dustin; Keller, Michelle; Denver, Dee R.; Baer, Charles F.; Estes, Suzanne

Citeable URL: https://ir.library.oregonstate.edu/concern/articles/th83m052z

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Creator	Joyner-Matos, Joanna Hicks, Kiley A. Cousins, Dustin Keller, Michelle Denver, Dee R. Baer, Charles F. Estes, Suzanne
Abstract	We explored the relationship between relaxed selection, oxidative stress, and spontaneous mutation in a set of mutation-accumulation (MA) lines of the nematode Caenorhabditis elegans and in their common ancestor. We measured steady-state levels of free radicals and oxidatively damaged guanosine nucleosides in the somatic tissues of five MA lines for which nuclear genome base substitution and GC-TA transversion frequencies are known. The two markers of oxidative stress are highly correlated and are elevated in the MA lines relative to the ancestor; point estimates of the per-generation rate of mutational decay (DM) of these measures of oxidative stress are similar to those reported for fitness-related traits. Conversely, there is no significant relationship between either marker of oxidative stress and the per-generation frequencies of base substitution or GC-TA transversion. Although these results provide no direct evidence for a causative relationship between oxidative damage and base substitution mutations, to the extent that oxidative damage may be weakly mutagenic in the germline, the case for condition-dependent mutation is advanced.
License	Attribution 3.0 United States
Resource Type	Article
DOI	https://doi.org/10.1371/journal.pone.0065604
Date Available	2013-09-04T22:06:18+00:00
Date Issued	2013-06-11
Citation	Joyner-Matos J, Hicks KA, Cousins D, Keller M, Denver DR, Baer CF, et al. (2013) Evolution of a Higher Intracellular Oxidizing Environment in Caenorhabditis elegans under Relaxed Selection. PLoS ONE 8(6): e65604. https://doi.org/10.1371/journal.pone.0065604
Journal Title	PLoS ONE
Journal Volume	8
Journal Issue/Number	6
Academic Affiliation	Integrative Biology
Rights Statement	In Copyright
Funding Statement (additional comments about funding)	This work was funded by an Eastern Washington University Start Something Big Grant to JJM (http://sites.ewu.edu/foundation/resources/startsomething-big-grant/); National Institutes of Health (http://www.nih.gov/) grant R01 GM072639 to CFB and DRD, National Institutes of Health grant 5 R01GM087628-02 to DRD and SE; PSU Faculty Enhancement grant to SE (http://www.pdx.edu/oaa/faculty-enhancement-grants) and American Heart Association Predoctoral Fellowship 11PRE4880069 to KAH (http://my.americanheart.org/professional/Research/FundingOpportunities/Funding-Opportunities_UCM_316909_SubHomePage.jsp). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher	Public Library of Science
Peer Reviewed	Yes
Language	English [eng]
Replaces	http://hdl.handle.net/1957/42268

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Evolution of a Higher Intracellular Oxidizing Environment in Caenorhabditis elegans under Relaxed Selection

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Evolution of a Higher Intracellular Oxidizing Environment in Caenorhabditis elegans under Relaxed Selection

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