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Evolution of a Higher Intracellular Oxidizing Environment in Caenorhabditis elegans under Relaxed Selection Public Deposited

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  • We explored the relationship between relaxed selection, oxidative stress, and spontaneous mutation in a set of mutation-accumulation (MA) lines of the nematode Caenorhabditis elegans and in their common ancestor. We measured steady-state levels of free radicals and oxidatively damaged guanosine nucleosides in the somatic tissues of five MA lines for which nuclear genome base substitution and GC-TA transversion frequencies are known. The two markers of oxidative stress are highly correlated and are elevated in the MA lines relative to the ancestor; point estimates of the per-generation rate of mutational decay (DM) of these measures of oxidative stress are similar to those reported for fitness-related traits. Conversely, there is no significant relationship between either marker of oxidative stress and the per-generation frequencies of base substitution or GC-TA transversion. Although these results provide no direct evidence for a causative relationship between oxidative damage and base substitution mutations, to the extent that oxidative damage may be weakly mutagenic in the germline, the case for condition-dependent mutation is advanced.
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  • Joyner-Matos, J., Hicks, K. A., Cousins, D., Keller, M., Denver, D. R., Baer, C. F., & Estes, S. (2013). Evolution of a higher intracellular oxidizing environment in Caenorhabditis elegans under relaxed selection. PloS One, 8(6), e65604. doi:10.1371/journal.pone.0065604
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  • description.provenance : Made available in DSpace on 2013-09-04T22:06:18Z (GMT). No. of bitstreams: 2 license_rdf: 1370 bytes, checksum: cd1af5ab51bcc7a5280cf305303530e9 (MD5) DenverDeeRZoologyEvolutionHigherIntracellular.pdf: 135880 bytes, checksum: 1da4bf810003b60f892d68d54be4ae13 (MD5) Previous issue date: 2013-06-11
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