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The effect of TCDD on cytokine production during the progression of insulitis in NOD mice Public Deposited

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  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent immunosuppressant, and suppresses many disease models including graft-versus-host (GVH), experimental autoimmune encephalomyelitis (EAE) and a model of type 1 diabetes in non-obese diabetic (NOD) mice (1-3). In this study, we show that the inflammation of the pancreas due to insulitis is not a systemic autoimmune response. When treatment with TCDD was terminated at 15 weeks of age, the pro-inflammatory cytokines IFN-gamma and IL-17 were not detectable in serum. Likewise, the tissue protective cytokine IL-22 was also not detectable in serum. Taken together, this suggests that the autoimmune response due to insulitis is localized to the pancreas.
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  • Howard Hughes Medical Institute (HHMI)
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  • description.provenance : Approved for entry into archive by Deanne Bruner(deanne.bruner@oregonstate.edu) on 2013-06-07T21:40:43Z (GMT) No. of bitstreams: 3 license_rdf: 1232 bytes, checksum: bb87e2fb4674c76d0d2e9ed07fbb9c86 (MD5) pham_HHMI_2012_presentation.pdf: 616829 bytes, checksum: c888dc370215c37027577ec1c21141c9 (MD5) pham_HHMI_2012_presentation.pptx: 894039 bytes, checksum: c00cb552cf0158970c5ab43441e45e6c (MD5)
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  • description.provenance : Made available in DSpace on 2013-06-07T21:40:43Z (GMT). No. of bitstreams: 3 license_rdf: 1232 bytes, checksum: bb87e2fb4674c76d0d2e9ed07fbb9c86 (MD5) pham_HHMI_2012_presentation.pdf: 616829 bytes, checksum: c888dc370215c37027577ec1c21141c9 (MD5) pham_HHMI_2012_presentation.pptx: 894039 bytes, checksum: c00cb552cf0158970c5ab43441e45e6c (MD5)
  • description.provenance : Submitted by Tuan Pham (phamtuan@onid.orst.edu) on 2013-06-06T17:53:15Z No. of bitstreams: 3 license_rdf: 1089 bytes, checksum: 0a703d871bf062c5fdc7850b1496693b (MD5) pham_HHMI_2012_presentation.pdf: 616829 bytes, checksum: c888dc370215c37027577ec1c21141c9 (MD5) pham_HHMI_2012_presentation.pptx: 894039 bytes, checksum: c00cb552cf0158970c5ab43441e45e6c (MD5)
  • description.provenance : Submitted by Tuan Pham (phamtuan@onid.orst.edu) on 2013-06-07T18:09:00Z No. of bitstreams: 3 license_rdf: 1232 bytes, checksum: bb87e2fb4674c76d0d2e9ed07fbb9c86 (MD5) pham_HHMI_2012_presentation.pdf: 616829 bytes, checksum: c888dc370215c37027577ec1c21141c9 (MD5) pham_HHMI_2012_presentation.pptx: 894039 bytes, checksum: c00cb552cf0158970c5ab43441e45e6c (MD5)

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