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Plasma metabolites altered by sulforaphane in humans Public Deposited

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  • Consuming cruciferous vegetables such as broccoli sprouts, kale, Brussels sprouts, and bok choy is associated with several health benefits, such as a decreased risk of certain cancers. Cruciferous vegetables contain the glucosinolate, glucoraphanin (GFN). Cutting, chopping or chewing these vegetables releases the enzyme myrosinase, which transforms GFN into sulforaphane (SFN). SFN has many demonstrated health benefits including anticarcinogenic, antioxidant, and antibacterial properties. SFN has been shown to target apoptosis and excretion of carcinogens, cell cycle arrest, and eradication of H. pylori infections. The purpose of this project was to identify new biological pathways altered by SFN consumption in humans and potential biomarkers of SFN action. To achieve this goal, we utilized novel metabolomics technologies that profile global metabolite levels in biological fluids. We evaluated metabolomic profiles following sprout consumption using high-performance liquid chromatography - tandem mass spectrometry in plasma from healthy human subjects consuming 200 µmol SFN equivalents from fresh broccoli sprouts. We observed changes in these metabolite profiles following SFN consumption. One feature significantly increased 48 hours following sprout consumption was matched to creatinine in the Human Metabolome Database. This information will improve understanding of SFN’s mechanisms of action and direct further study of SFN’s role in human health.
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  • Corvallis, Oregon, USA
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  • This overarching project was supported by NIH grants CA090890, CA122906, NIEHS grant P30 ES000210. We gratefully acknowledge technical assistance from Lauren Atwell, Dr. Carmen Wong, Dr. Laura Beaver, Karin Hardin and Jeff Morré. Broccoli sprouts were provided by Sprouters NW, Inc.
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  • description.provenance : Made available in DSpace on 2014-06-06T18:07:33Z (GMT). No. of bitstreams: 2 CUE final poster 5-13-14 - Kim Kelsey.pdf: 390123 bytes, checksum: 8e3e32e3269b43f4a1a4220311adde82 (MD5) CUE final poster 5-13-14 - Kim Kelsey.pptx: 552941 bytes, checksum: 6ca03b2381b73480ab14e0cf3a6cd462 (MD5)
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2014-06-06T18:07:33Z (GMT) No. of bitstreams: 2 CUE final poster 5-13-14 - Kim Kelsey.pdf: 390123 bytes, checksum: 8e3e32e3269b43f4a1a4220311adde82 (MD5) CUE final poster 5-13-14 - Kim Kelsey.pptx: 552941 bytes, checksum: 6ca03b2381b73480ab14e0cf3a6cd462 (MD5)
  • description.provenance : Submitted by Kimberly Kelsey (kelseyk) on 2014-06-06T17:51:22Z No. of bitstreams: 2 CUE final poster 5-13-14 - Kim Kelsey.pdf: 390123 bytes, checksum: 8e3e32e3269b43f4a1a4220311adde82 (MD5) CUE final poster 5-13-14 - Kim Kelsey.pptx: 552941 bytes, checksum: 6ca03b2381b73480ab14e0cf3a6cd462 (MD5)

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