Short-Term Treatment With Rapamycin and Dietary Restriction Have Overlapping and Distinctive Effects in Young Mice Public Deposited

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  • Because rapamycin, an inhibitor of the nutrient sensor mammalian target of rapamycin, and dietary restriction both increase life span of mice, it has been hypothesized that they act through similar mechanisms. To test this hypothesis, we compared various biological parameters in dietary restriction mice (40% food restriction) and mice fed rapamycin (14 ppm). Both treatments led to a significant reduction in mammalian target of rapamycin signaling and a corresponding increase in autophagy. However, we observed striking differences in fat mass, insulin sensitivity, and expression of cell cycle and sirtuin genes in mice fed rapamycin compared with dietary restriction. Thus, although both treatments lead to significant downregulation of mammalian target of rapamycin signaling, these two manipulations have quite different effects on other physiological functions suggesting that they might increase life span through a common pathway as well as pathways that are altered differently by dietary restriction and rapamycin.
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  • Fok, W. C., Pérez, V. I., Zhang, Y., Salmon, A. B., Bhattacharya, A., Gunda, R., . . . Richardson, A. (2013). Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 68(2), 108.
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  • description.provenance : Approved for entry into archive by Deborah Campbell(deborah.campbell@oregonstate.edu) on 2013-03-05T21:07:28Z (GMT) No. of bitstreams: 3 license_rdf: 22765 bytes, checksum: 56265f5776a16a05899187d30899c530 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) PerezVivianaIBiochemistryBiophysicsShortTermTreatment.pdf: 1055312 bytes, checksum: 80a53398958493b8fa501af6258a97a7 (MD5)
  • description.provenance : Made available in DSpace on 2013-03-05T21:07:28Z (GMT). No. of bitstreams: 3 license_rdf: 22765 bytes, checksum: 56265f5776a16a05899187d30899c530 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) PerezVivianaIBiochemistryBiophysicsShortTermTreatment.pdf: 1055312 bytes, checksum: 80a53398958493b8fa501af6258a97a7 (MD5) Previous issue date: 2013-02
  • description.provenance : Submitted by Deborah Campbell (deborah.campbell@oregonstate.edu) on 2013-03-05T17:00:55Z No. of bitstreams: 3 license_rdf: 22765 bytes, checksum: 56265f5776a16a05899187d30899c530 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) PerezVivianaIBiochemistryBiophysicsShortTermTreatment.pdf: 1055312 bytes, checksum: 80a53398958493b8fa501af6258a97a7 (MD5)

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