Article
 

Short-Term Treatment With Rapamycin and Dietary Restriction Have Overlapping and Distinctive Effects in Young Mice

公开 Deposited

可下载的内容

下载PDF文件
https://ir.library.oregonstate.edu/concern/articles/z316q250b

Descriptions

Attribute NameValues
Creator
Abstract
  • Because rapamycin, an inhibitor of the nutrient sensor mammalian target of rapamycin, and dietary restriction both increase life span of mice, it has been hypothesized that they act through similar mechanisms. To test this hypothesis, we compared various biological parameters in dietary restriction mice (40% food restriction) and mice fed rapamycin (14 ppm). Both treatments led to a significant reduction in mammalian target of rapamycin signaling and a corresponding increase in autophagy. However, we observed striking differences in fat mass, insulin sensitivity, and expression of cell cycle and sirtuin genes in mice fed rapamycin compared with dietary restriction. Thus, although both treatments lead to significant downregulation of mammalian target of rapamycin signaling, these two manipulations have quite different effects on other physiological functions suggesting that they might increase life span through a common pathway as well as pathways that are altered differently by dietary restriction and rapamycin.
  • Keywords: Autophagy, mTOR, Dietary restriction, Rapamycin, Gene expression
Resource Type
DOI
Date Available
Date Issued
Citation
  • Fok, W. C., Pérez, V. I., Zhang, Y., Salmon, A. B., Bhattacharya, A., Gunda, R., . . . Richardson, A. (2013). Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 68(2), 108.
Journal Title
Journal Volume
  • 68
Journal Issue/Number
  • 2
Academic Affiliation
权利声明
Funding Statement (additional comments about funding)
  • Financial support was provided by The San Antonio Nathan Shock Aging Center (1P30-AG-13319 to A.R.), National Institutes of Health (NIH) RC2 Grand Opportunity grant (AG036613 to A.R.), NIH T32 Training Grant (AG021890 to W.C.F.), and The Ellison Medical Foundation (to V.I.P.).
Publisher
Peer Reviewed
Language
Replaces

关联

Parents:

This work has no parents.

单件

缩略图 标题 上传日期 公开度 行动
file details PerezVivianaIBiochemistryBiophysicsShortTermTreatment.pdf 2017-07-10 公开 下载