Kidney Function and Mortality in Octogenarians: Cardiovascular Health Study All Stars Public Deposited

http://ir.library.oregonstate.edu/concern/defaults/z890rv037

This is the publisher’s final pdf. The article is copyrighted by The American Geriatrics Society and published by John Wiley & Sons, Inc. It can be found at:  http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291532-5415/. To the best of our knowledge, one or more authors of this paper were federal employees when contributing to this work.

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • Objectives: To examine the association between kidney function and all-cause mortality in octogenarians. Design Retrospective analysis of prospectively collected data. Setting: Community. Participants: Serum creatinine and cystatin C were measured in 1,053 Cardiovascular Health Study (CHS) All Stars participants. Measurements: Estimated glomerular filtration rate (eGFR) was determined using the Chronic Kidney Disease Epidemiology Collaboration creatinine (eGFR[subscript CR]) and cystatin C one-variable (eGFR[subscript CYS]) equations. The association between quintiles of kidney function and all-cause mortality was analyzed using unadjusted and adjusted Cox proportional hazards models. Results: Mean age of the participants was 85, 64% were female, 66% had hypertension, 14% had diabetes mellitus, and 39% had prevalent cardiovascular disease. There were 154 deaths over a median follow-up of 2.6 years. The association between eGFR[subscript CR] and all-cause mortality was U-shaped. In comparison with the reference quintile (64–75 mL/min per 1.73 m²), the highest (≥75 mL/min per 1.73 m²) and lowest (≤43 mL/min per 1.73 m²) quintiles of eGFR[subscript CR] were independently associated with mortality (hazard ratio (HR) = 2.49, 95% confidence interval (CI) = 1.36–4.55; HR = 2.28, 95% CI = 1.26–4.10, respectively). The association between eGFR[subscript CYS] and all-cause mortality was linear in those with eGFR[subscript CYS] of less than 60 mL/min per 1.73 m², and in the multivariate analyses, the lowest quintile of eGFR[subscript CYS] (<52 mL/min per 1.73 m²) was significantly associated with mortality (HR = 2.04, 95% CI = 1.12–3.71) compared with the highest quintile (>0.88 mL/min per 1.73 m²). Conclusion: Moderate reduction in kidney function is a risk factor for all-cause mortality in octogenarians. The association between eGFR[subscript CR] and all-cause mortality differed from that observed with eGFR[subscript CYS]; the relationship was U-shaped for eGFR[subscript CR], whereas the risk was primarily present in the lowest quintile for eGFR[subscript CYS].
Resource Type
DOI
Date Available
Date Issued
Citation
  • Shastri, S., Katz, R., Rifkin, D. E., Fried, L. F., Odden, M. C., Peralta, C. A., Chonchol, M., Siscovick, D., Shlipak, M. G., Newman, A. B. and Sarnak, M. J. (2012), Kidney Function and Mortality in Octogenarians: Cardiovascular Health Study All Stars. Journal of the American Geriatrics Society, 60: 1201–1207. doi: 10.1111/j.1532-5415.2012.04046.x
Academic Affiliation
Series
Keyword
Rights Statement
Funding Statement (additional comments about funding)
Publisher
Peer Reviewed
Language
Replaces
Additional Information
  • description.provenance : Made available in DSpace on 2012-08-21T20:10:16Z (GMT). No. of bitstreams: 1 OddenMichellePublicHealthKidneyFunctionMortality.pdf: 132878 bytes, checksum: 2c54254dd805de930f256fc57c59a532 (MD5) Previous issue date: 2012-07
  • description.provenance : Submitted by Deanne Bruner (deanne.bruner@oregonstate.edu) on 2012-08-21T01:19:42Z No. of bitstreams: 1 OddenMichellePublicHealthKidneyFunctionMortality.pdf: 132878 bytes, checksum: 2c54254dd805de930f256fc57c59a532 (MD5)
  • description.provenance : Approved for entry into archive by Deanne Bruner(deanne.bruner@oregonstate.edu) on 2012-08-21T20:10:16Z (GMT) No. of bitstreams: 1 OddenMichellePublicHealthKidneyFunctionMortality.pdf: 132878 bytes, checksum: 2c54254dd805de930f256fc57c59a532 (MD5)

Relationships

In Administrative Set:
Last modified: 07/13/2017

Downloadable Content

Download PDF
Citations:

EndNote | Zotero | Mendeley

Items