Meriones unguiculatus, a new experimental host for Fasciola hepatica Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/02870z185

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • The literature relating to fascioliasis in experimental hosts, and the clawed jird (Meriones unguiculatus) as an experimental host was reviewed. Four experiments were conducted using experimental hosts for Fasciola hepatica. The first two experiments were done using Swiss mice, B. P. laboratory albino strain; the third and fourth experiments involved the clawed jird. The metacercariae of F. hepatica used in the first three experiments were obtained from Weybridge, England, and from Lymnaeid snails maintained by the Department of Veterinary Medicine, Oregon State University, Corvallis, Oregon. Metacercariae from the latter source were used in experiment number four. An individual dose of 20 and 10 metacercariae proved fatal to mice 26 to 29 and 27 to 31 days following infection, respectively. A similar fatality pattern was observed in experiment number three from day 27 through 33, when the clawed jird was infected with 20 metacercariae. In experiment number four, the dosage of metacercariae given to five groups of clawed jirds was as follows: 1, 2, 4, 8, and 16. Similar death losses were observed in animals receiving 4, 8 and 16 metacercariae from day 26 through 36. No lesions were observed in the two groups receiving one and two metacercariae, or the controls. The absence of lesions in the two infected groups was attributed to the administration of nonviable metacercariae. Necropsy of infected animals that died revealed hemoperitoneum, fibrinous peritonitis, and severe hepatic necrosis. Histological examination of liver sections from these animals revealed necrosis, infarction, and organized hemorrhages. Evidence of inflammatory response was observed around the fluke's burrows and the hepatic trinities. Biliary hyperplasia was evident and flukes were observed in the hepatic parenchyma. Flukes recovered from the liver and from peritoneal washings compared favorably in size with previous reports in mice. The mouse as an experimental host for fascioliasis has been established by others. This study confirmed this finding. Although F. hepatica was not observed to complete its life cycle in the clawed jird, the susceptibility of this host for F. hepatica was demonstrated.
Resource Type
Date Available
Date Copyright
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Academic Affiliation
Non-Academic Affiliation
Subject
Rights Statement
Peer Reviewed
Language
Digitization Specifications
  • File scanned at 300 ppi using ScandAll PRO 1.8.1 on a Fi-6770A in PDF format. CVista PdfCompressor 4.0 was used for pdf compression and textual OCR.
Replaces
Additional Information
  • description.provenance : Submitted by Lauren Kaysen (lkscannerosu@gmail.com) on 2014-05-07T17:06:45Z No. of bitstreams: 1 HelferDonaldH1966.pdf: 1610538 bytes, checksum: 6bb6955802651621f5c8822aff22b10b (MD5)
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2014-05-08T17:47:42Z (GMT) No. of bitstreams: 1 HelferDonaldH1966.pdf: 1610538 bytes, checksum: 6bb6955802651621f5c8822aff22b10b (MD5)
  • description.provenance : Approved for entry into archive by Katy Davis(kdscannerosu@gmail.com) on 2014-05-12T16:47:33Z (GMT) No. of bitstreams: 1 HelferDonaldH1966.pdf: 1599005 bytes, checksum: 61783b2f580d6f53d3330519f5fc8adc (MD5)
  • description.provenance : Made available in DSpace on 2014-05-12T16:47:33Z (GMT). No. of bitstreams: 1 HelferDonaldH1966.pdf: 1599005 bytes, checksum: 61783b2f580d6f53d3330519f5fc8adc (MD5) Previous issue date: 1966-05-05
  • description.provenance : Submitted by Lauren Kaysen (lkscannerosu@gmail.com) on 2014-05-09T19:33:55Z No. of bitstreams: 1 HelferDonaldH1966.pdf: 1599005 bytes, checksum: 61783b2f580d6f53d3330519f5fc8adc (MD5)
  • description.provenance : Rejected by Patricia Black(patricia.black@oregonstate.edu), reason: Replace on 2014-05-09T19:30:48Z (GMT)
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2014-05-09T19:39:59Z (GMT) No. of bitstreams: 1 HelferDonaldH1966.pdf: 1599005 bytes, checksum: 61783b2f580d6f53d3330519f5fc8adc (MD5)

Relationships

In Administrative Set:
Last modified: 08/04/2017

Downloadable Content

Download PDF
Citations:

EndNote | Zotero | Mendeley

Items