Graduate Thesis Or Dissertation

 

Dissolution and bioavailability of immediate and sustained release cold and cough dosage forms Public Deposited

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https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/08612r63g

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  • A high-pressure liquid chromatography method based on reported literature was developed for the quantitative analysis of chlorpheniramine, pseudoephedrine, phenylpropanolamine and acetaminophen in dissolution fluids and urine. The effects of buffer, pH and different concentrations of organic solvent in the mobile phase on chromatographic separation are described in Chapter I. Dissolution studies using the USP rotating-basket method were carried out on several commercially available brands of sustained and immediate release products. Dissolution pattern comparisons among products provided preliminary data before conducting a relative bioavailability study. Relative bioavailability of chlorpheniramine from one immediate and two sustained-release products was determined in a urinary excretion study using 4 normal healthy subjects. Urinary excretion of acetaminophen was also studied in these four subjects. Bioavailability results were consistent with dissolution results.
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