Graduate Thesis Or Dissertation

 

The effect of 2, 4-dichlorophenoxyacetic acid on the vivo metabolism of acetate in rats Public Deposited

Downloadable Content

Download PDF
https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/0c483n15b

Descriptions

Attribute NameValues
Creator
Abstract
  • Normal adult rats absorbed and metabolized C¹⁴-labeled acetate rapidly. The greatest percentage of the administered radioactivity was recovered in the expired CO₂, however small amounts of radioactivity were also found in the urine and feces. There were two rates of C¹⁴O₂ elimination in normal adult rats. The small amount of radioactivity recovered in the urine was found to consist of several different metabolites; their relative abundance was dependent upon the sex of the rat and the C¹⁴-labeled acetate used. Orally administered 2,4-D was found to effect the secondary rate of C¹⁴O₂ elimination, and to reduce the percentage of radioactivity recovered. The presence of 2,4-D altered the pattern of radioactive metabolites found in the urine. In females, the effect of 2,4-D was greater on the metabolism of the methyl carbon than on the carboxyl carbon of acetate. The presence of 2,4-D was found to have a similar effect on the rate of C¹⁴O₂ elimination over a wide range of dosages. At lower dosages, five milligrams or less per rat, the effect was reduced. The accumulative recovery of radioactivity was increased as the dosage of 2,4-D was decreased. When the time between 2,4-D treatment and acetate administration was increased, up to 48 hours, a similar effect on the C¹⁴O₂ elimination rate was observed. However, there was a trend toward greater recovery of the radioactivity. With a pretreatment time of one week, 2,4-D showed no effect on the acetate metabolism. Large amounts of radioactivity were found in the stomach of rats given 2,4-D and acetate-1-C¹⁴ orally. From this it was concluded that 2,4-D was affecting the absorption of acetate. This conclusion was further verified when 2,4-D was given orally, and acetate was injected into the peritoneal cavity. In this work,2,4-D did not alter the C¹⁴O₂ elimination pattern, although there was a slight reduction in the percentage of the radioactivity recovered.
Resource Type
Date Available
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Academic Affiliation
Non-Academic Affiliation
Subject
Rights Statement
Publisher
Peer Reviewed
Language
Digitization Specifications
  • File scanned at 300 ppi using Capture Perfect 3.0 on a Canon DR-9050C in PDF format. CVista PdfCompressor 5.0 was used for pdf compression and textual OCR.
Replaces
Additional Information
  • description.provenance : Approved for entry into archive by Katy Davis(kdscannerosu@gmail.com) on 2014-04-29T15:29:04Z (GMT) No. of bitstreams: 1 PhilleoWilliamW1966.pdf: 1147709 bytes, checksum: 2e753ea092898ce7b4e34f7eddfd8d1a (MD5)
  • description.provenance : Made available in DSpace on 2014-04-29T15:29:04Z (GMT). No. of bitstreams: 1 PhilleoWilliamW1966.pdf: 1147709 bytes, checksum: 2e753ea092898ce7b4e34f7eddfd8d1a (MD5) Previous issue date: 1965-07-29
  • description.provenance : Submitted by Madison Medley (mmscannerosu@gmail.com) on 2014-04-24T17:16:17Z No. of bitstreams: 1 PhilleoWilliamW1966.pdf: 1147709 bytes, checksum: 2e753ea092898ce7b4e34f7eddfd8d1a (MD5)
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2014-04-24T17:40:28Z (GMT) No. of bitstreams: 1 PhilleoWilliamW1966.pdf: 1147709 bytes, checksum: 2e753ea092898ce7b4e34f7eddfd8d1a (MD5)

Relationships

Parents:

This work has no parents.

In Collection:

Items