Effects of chronic estrogen treatment on uterine nucleic acids Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/0r9676541

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  • The effects of estrogen treatment on uterine weight, uterine nucleic acid content and adrenal weight were studied. Daily doses of 0.05μg or 0.1 μg of Estradiol 17-β were administered subcutaneously to seven day castrated female rats for periods varying from 0 to 168 days. After two days of treatment uterine weight, total uterine RNA and RNA/DNA ratio showed marked increases over the castrate condition. The rapid uterine growth occurring during the first two days ceased and the uterine weights were maintained close to the levels of the two day response for periods of treatment as long as 48 days. This cessation of uterine growth was accompanied by a decline in total RNA and RNA/DNA ratio. There were no significant changes in total DNA during these periods. The ability of the uterus to respond to changing levels of estrogen treatment was tested during the period of cessation of growth and decline in RNA. After 35 days at a constant dosage the uterus responded to an increase in dosage with rapid growth and marked increases in total RNA and RNA/DNA ratio with no significant change in total DNA. After two days at the higher dosage these increases leveled off even though treatment was continued at the higher level. The uterus responded to a lowering of the dosage with a drop in uterine weight, total RNA and RNA/DNA ratio with no significant change in total DNA. Beginning at about 48 days of treatment all groups, irrespective of previous treatments, showed increasing values for total RNA, RNA/DNA ratio and uterine weight. At periods of treatment under 60 days there was little evidence of a significant increase over zero time values, in total DNA. However, most of the groups autopsied after 119 days or more of estrogen treatment showed values for total DNA which were markedly higher than the total DNA value at zero time. After prolonged treatment many of the groups showed a great deal of variability with certain individuals having very high values for uterine weight, total RNA and total DNA. Sometimes these large uteri were covered with small nodules under the uterine peritoneum. Pending histological examination these are thought to be due to endometrial glandular hyperplasia, with the bases of the endometrial glands having proliferated out through the muscularis.
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  • description.provenance : Submitted by Georgeann Booth (gbscannerosu@gmail.com) on 2014-05-30T23:58:53Z No. of bitstreams: 1 RinardGilbert1964.pdf: 1423634 bytes, checksum: a7f1aef6ff6e6f63da3b10fbeafd9680 (MD5)
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